SPRN Antibody

中文名称：

SPRN兔多克隆抗体
货号：

CSB-PA058370
规格：

￥1100
图片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA058370(SPRN Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA058370(SPRN Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

产品详情

Uniprot No.：

Q5BIV9
基因名：

SPRN
别名：

SPRN antibody; SHO antibody; Shadow of prion protein antibody; Protein shadoo antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Synthetic peptide of Human SPRN
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
抗体亚型：

IgG
纯化方式：

Antigen affinity purification
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
产品提供形式：

Liquid
应用范围：

ELISA,IHC
推荐稀释比：

Application Recommended Dilution

ELISA 1:1000-1:2000

IHC 1:25-1:100
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.
基因功能参考文献：
1. Shadoo is degraded in Scrapie-infected rodents and cultured cells mediated by proteasome degradation after modification by ubiquitination. PMID: 24390475
2. a conserved physiological activity between PrP(C) and Sho to protect cells from stress-induced toxicity and suggests that Sho and PrP(C) might act on similar signaling pathways. PMID: 21257747
3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
6. A novel solid phase technology for high- throughput synthesis of the SPRN gene is reported. PMID: 18778261
7. Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease PMID: 18805828
8. Observational study of gene-disease association. (HuGE Navigator) PMID: 18805828
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亚细胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

SPRN family
组织特异性：

Mainly expressed in brain. In brain, it is expressed in hippocampus.
数据库链接：

HGNC: 16871

OMIM: 610447

KEGG: hsa:503542

STRING: 9606.ENSP00000433712

UniGene: Hs.64968

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:25-1:100