SPC24 Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) SPC24 Polyclonal antibody
Uniprot No.：

Q8NBT2
基因名：

SPC24
别名：

FLJ90806 antibody; hSpc24 antibody; Kinetochore protein Spc24 antibody; SPBC24 antibody; spc24 antibody; SPC24 NDC80 kinetochore complex component antibody; SPC24 NDC80 kinetochore complex component homolog antibody; SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) antibody; SPC24_HUMAN antibody; Spindle pole body component 24 homolog (S. cerevisiae) antibody; Spindle pole body component 24 homolog antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Kinetochore protein Spc24 protein (21-97AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
基因功能参考文献：
1. SPC24 is up-regulated in human breast cancer.SPC24 regulates PI3K/AKT kinase pathway in breast cancer. PMID: 30180968
2. our data demonstrates that SPC24 can serve as a promising prognostic biomarker of anaplastic thyroid cancer cells PMID: 28423533
3. Data indicate that kinetochore protein Spc24 (SPC24) may be a promising molecular target for hepatocellular carcinoma (HCC) therapy. PMID: 26515591
4. hSPC24 is a component of the human NDC80 kinetochore complex PMID: 14699129
亚细胞定位：

Nucleus. Chromosome, centromere, kinetochore.
蛋白家族：

SPC24 family
数据库链接：

HGNC: 26913

OMIM: 609394

KEGG: hsa:147841

STRING: 9606.ENSP00000465075

UniGene: Hs.381225