SOX30 Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) SOX30 Polyclonal antibody
Uniprot No.：

O94993
基因名：

SOX30
别名：

SOX30 antibody; Transcription factor SOX-30 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Transcription factor SOX-30 protein (84-206AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as both a transcriptional activator and repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4.
基因功能参考文献：
1. these results highlight an important role and mechanism of SOX30 in lung cancer metastasis, providing a potential therapeutic target for anti-metastasis. PMID: 29739711
2. SOX30 expression represents an important prognostic factor for survival time in lung adenocarcinoma patients. PMID: 26330328
3. Blockade of p53 attenuates the tumor inhibition of SOX30. PMID: 25435374
亚细胞定位：

Nucleus. Cytoplasm.
数据库链接：

HGNC: 30635

OMIM: 606698

KEGG: hsa:11063

STRING: 9606.ENSP00000265007

UniGene: Hs.529462