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  4. SLC38A1 Antibody

SLC38A1 Antibody

说明书
  • 中文名称：
    SLC38A1兔多克隆抗体
  • 货号：
    CSB-PA021614GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H2H9
  • 基因名：
    SLC38A1
  • 别名：
    Amino acid transporter A1 antibody; Amino acid transporter system A1 antibody; ATA 1 antibody; ATA1 antibody; N-system amino acid transporter 2 antibody; NAT 2 antibody; NAT2 antibody; S38A1_HUMAN antibody; SAT 1 antibody; SAT1 antibody; SLC38A1 antibody; SNAT 1 antibody; SNAT1 antibody; Sodium-coupled neutral amino acid transporter 1 antibody; Solute carrier family 38 member 1 antibody; System A amino acid transporter 1 antibody; System N amino acid transporter 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SLC38A1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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SLC38A1 Proteins

靶点详情

  • 功能：
    Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
  • 基因功能参考文献：
    1. High SNAT1 expression is associated with increased cell migration in breast neoplasms. PMID: 27048259
    2. this study indicates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, and provides a new insight into the role and mechanism of insulin-induced glycolysis. PMID: 27613819
    3. Results found that SLC38A1 was up-regulated in colorectal cancer cells (CRC) and significantly associated with tumor invasion and advanced disease stage. Its overexpression enhanced growth and migration of HCT116 cells providing evidence that activation of SLC38A1 may play a critical role in CRC development and progression. PMID: 28224429
    4. The SLC38A1 protein was very low or undetectable in healthy gastric mucosa but strong staining of SLC38A1 protein was found in the cytoplasm in more than half of gastric cancer samples. SLC38A1 knockdown decreased tumor cell proliferation and migration. PMID: 24712400
    5. The cross-talk between Akt signaling and SNAT1 might play a critical role in the development and progression of breast cancer PMID: 23848995
    6. Increased expression of ATA1 is frequent in human hilar cholangiocarcinoma and significantly correlated with the progression of cholangiocarcinoma, suggesting the importance of ATA1 in cancer development and progression. PMID: 20605601
    7. The results of this study provided that RAB2A and SLC38A1, were associated with the density of calbindin-positive neurons and the number of perineuronal oligodendrocytes in psychiatric disorders. PMID: 20308991
    8. results suggest that slc38a1 may play a role in the mechanisms underlying the determination of cellular viability in astrocytes through modulation of intracellular ROS generation PMID: 21219957
    9. SNAT1 is a key contributor to system A activity at term. PMID: 20599747
    10. Theses data demonstrate the physiological importance of ATA1 in hepatocarcinogenesis. PMID: 17549407
    11. Report SNAT1 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
    12. A possible association between low expression of SNAT1 and suicidal behavior is suggested. PMID: 19442705

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid/polyamine transporter 2 family
  • 组织特异性：
    Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis.
  • 数据库链接：

    HGNC: 13447

    OMIM: 608490

    KEGG: hsa:81539

    STRING: 9606.ENSP00000381634

    UniGene: Hs.533770

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