SLC26A9 Antibody, FITC conjugated

1. Treatment response to ivacaftor, which aims to improve CFTR-channel opening probability in cystic fibrosis patients with gating mutations, shows substantial variability in response, 28% of which can be explained by rs7512462 in SLC26A9. PMID: 28171547
2. when SLC26A9 is coexpressed with F508del CFTR, its trafficking defect leads to a PDZ motif-sensitive intracellular retention of SLC26A9. PMID: 28360110
3. SLC26A9 single nucleotide polymorphisms modify prenatal exocrine pancreatic damage in cystic fibrosis PMID: 25771386
4. We have identified two SLC26A9 mutations decreasing Cl- channel transport in patients with a CF-like lung disease. PMID: 24272871
5. SLC26A9 is an epithelial chloride/bicarbonate channel that can interact with the CF transmembrane regulator (CFTR), the protein mutated in CF PMID: 23670970
6. Several SNPs in the 3' UTR of SLC26A9 (rs12031234, rs2282429, rs2282430)were associated with asthma in children with asthma. PMID: 22945630
7. SLC26A9 polymorphisms lead to several function modifications (increased activity, decreased activity, altered protein expression), which could lead to a spectrum of pathophysiologies. PMID: 22544634
8. Single nucleotide polymorphism in SLC26A9 gene is associated with cystic fibrosis. PMID: 22466613
9. Report functional interaction between CFTR and SLC26A9 in polarized airway epithelial cells and in non-polarized HEK293 cells. PMID: 21809345
10. the L683P mutation of SLC26A9 was found to reduce Cl(-) transport through SLC26A9 as well as the positive interaction exerted by SLC26A9 on CFTR ion transport activity PMID: 21439353
11. The interactions between SLC26A9 and CFTR were studied, and an alternative hypothesis to their known interactions is presented. PMID: 20658517
12. Functions as an anion conductance in the apical membranes of bronchial epithelium; contributes to transepithelial chloride currents under basal and cyclic AMP/protein kinase A-stimulated conditions. PMID: 19289574
13. Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport. PMID: 17120765
14. SLC26A9 is a highly selective Cl(-) channel with minimal OH(-)/HCO(3)(-) permeability that is regulated by the WNK kinases. PMID: 17673510
15. The transport properties of human SLC26A9 was studied to determine its functional and pharmacological characteristics. PMID: 18769029
16. These results imply that Slc26-STAS domains may all interact with (R)CFTR but that the physiological outcome is specific to differing Slc26 proteins, allowing for dynamic and acute fine tuning of ion transport for various epithelia. PMID: 19643730

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HGNC: 14469

OMIM: 608481

KEGG: hsa:115019

STRING: 9606.ENSP00000341682

UniGene: Hs.164073