SLC22A9 Antibody, Biotin conjugated

中文名称：

SLC22A9兔多克隆抗体, Biotin偶联
货号：

CSB-PA811607LD01HU
规格：

￥880
其他：

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产品名称：

Rabbit anti-Homo sapiens (Human) SLC22A9 Polyclonal antibody
Uniprot No.：

Q8IVM8
基因名：

SLC22A9
别名：

SLC22A9 antibody; hOAT4 antibody; OAT7 antibody; UST3 antibody; Solute carrier family 22 member 9 antibody; Organic anion transporter 7 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Solute carrier family 22 member 9 protein (45-143AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.
基因功能参考文献：
1. two human organic anion transporters OAT2 and OAT7 activities were assessed. PMID: 28945155
2. Pravastatin is the first identified OAT7 drug substrate. Substantial inter-individual variability in hepatic OAT7 expression, majorly driven by HNF4alpha, may contribute to pravastatin drug disposition and might affect response. PMID: 26239079
3. uptake of steroid sulfates by isolated trophoblasts is mediated by OATP-B and OAT-4 suggesting a physiological role of both carrier proteins in placental uptake of fetal-derived steroid sulfates. PMID: 12409283
4. Both progesterone and activation of PKC inhibited hOAT4 activity through redistribution of the transporter from cell surface to the intracellular compartments. PMID: 17341544
5. OAT7 is the first liver-specific transporter among members of the organic anion transporters of SLC22 family. PMID: 17393504
6. The data provide a model for the concerted action of OAT1 mediating apical secretion of glutarate derivatives from proximal tubule cells PMID: 18365245
7. The regulatory single nucleotide polymorphism (SNP) of OAT4 found in the promoter region of nephrectomized patients is unlikely to influence mRNA expression or promoter activity of OAT4. PMID: 18414781
8. Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of solute carrier family (SLC22) member 9. PMID: 18466105
9. Functional differences in steroid uptake of SLC22A9 and SLC02B1 in human placenta are reported. PMID: 18501590
10. Human organic anion transporter hOAT4 is a transporter of perfluorooctanoic acid. PMID: 19371258
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亚细胞定位：

Basolateral cell membrane; Multi-pass membrane protein. Note=Enriched at the sinusoidal part of the plasma membrane.
蛋白家族：

Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
组织特异性：

Specifically expressed in liver by hepatocytes (at protein level).
数据库链接：

HGNC: 16261

OMIM: 607579

KEGG: hsa:114571

STRING: 9606.ENSP00000279178

UniGene: Hs.502772

SLC22A9 Antibody, Biotin conjugated

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