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SIPA1 Antibody

说明书
  • 中文名称：
    SIPA1兔多克隆抗体
  • 货号：
    CSB-PA021330LA01HU
  • 规格：
    ￥440
  • 图片：
    • Western Blot
      Positive WB detected in: HL60 whole cell lysate
      All lanes: SIPA1 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 112 kDa
      Observed band size: 130 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA021330LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA021330LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA021330LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SIPA1 Polyclonal antibody
  • Uniprot No.：
    Q96FS4
  • 基因名：
    SIPA1
  • 别名：
    GTPase activating protein Spa 1 antibody; GTPase-activating protein Spa-1 antibody; MGC102688 antibody; MGC17037 antibody; p130 SPA-1 antibody; p130 SPA1 antibody; Signal induced proliferation associated 1 antibody; Signal induced proliferation associated gene 1 antibody; Signal induced proliferation associated protein 1 antibody; Signal-induced proliferation-associated protein 1 antibody; SIPA 1 antibody; Sipa-1 antibody; Sipa1 antibody; SIPA1_HUMAN antibody; Spa1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Signal-induced proliferation-associated protein 1 protein (759-927AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SIPA1 Antibody (CSB-PA021330LA01HU)，的标记方式是Non-conjugated。对于SIPA1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021330LB01HU SIPA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA021330LC01HU SIPA1 Antibody, FITC conjugated
    Biotin CSB-PA021330LD01HU SIPA1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
    Immunofluorescence (IF) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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SIPA1 antibodies

SIPA1 Proteins

靶点详情

  • 功能：
    GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression.
  • 基因功能参考文献：
    1. SIPA1 promotes oral squamous cell carcinoma metastasis by regulating the ITGB1 and MMP7. PMID: 28237246
    2. Study shows that SIPA1 mRNA and protein expression are down-regulated in gastric cancer cells and correlate with tumor grading, invasion and lymph node metastasis as well as higher expression of VEGFA. Low SIPA1 levels in gastric cancer may then accelerate tumor development and progression by promoting VEGFA expression to increase vascular density. PMID: 28362978
    3. results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis PMID: 26901824
    4. Our results indicate, for the first time, that the SIPA1 -313A>G may have a prognostic role in unresected NSCLC making it a potential predictor of poor survival due to earlier progression. PMID: 25352027
    5. nuclear SIPA1 contributes to breast cancer cell invasion through the regulation of integrin beta1 signaling. PMID: 24704834
    6. BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane. PMID: 24260471
    7. This meta-analysis suggests that rs746429 is associated with the risk of breast cancer. PMID: 24006220
    8. SIPA1 SNPs, rs746429 and rs2306364, were associated with decreased risk of triple-negative breast tumors. PMID: 23771732
    9. Polymorphism in Sipa1 promoter gene is associated with lung cancer. PMID: 23661532
    10. Patients with metastatic breast cancer with SIPA1 545 T/T genotype had a significantly worse overall survival than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). PMID: 23358895
    11. SIPA1 expression is increased in human colorectal cancer. PMID: 22990111
    12. In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 after controlling for stage and lymphvascular space invasion. PMID: 19906411
    13. Data identif a Rap GTPase-activating protein, signal-induced proliferation-associated protein 1 (SPA-1), as a factor that interacts with Brd4. PMID: 15456879
    14. SIPA1 germline polymorphisms are associated with aggressive disease behavior in breast cancer. PMID: 16563182
    15. SPA1 regulates the maintenance and differentiation of embryonic stem cells. PMID: 18033671
    16. it is unlikely that SIPA1 plays a pathogenetic role in the development of juvenile myelomonocytic leukemia PMID: 18492118
    17. Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival PMID: 19089925
    18. SIPA1 SNP rs3741378 was associated with increased breast cancer incidence. PMID: 19765277

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  • 亚细胞定位：
    Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein.
  • 组织特异性：
    Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
  • 数据库链接：

    HGNC: 10885

    OMIM: 602180

    KEGG: hsa:6494

    STRING: 9606.ENSP00000377771

    UniGene: Hs.530477

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