SCAF4 Antibody

产品详情

Uniprot No.：

O95104
基因名：

SCAF4
别名：

SCAF4 antibody; KIAA1172 antibody; SFRS15 antibody; SR-related and CTD-associated factor 4 antibody; CTD-binding SR-like protein RA4 antibody; Splicing factor antibody; arginine/serine-rich 15 antibody
宿主：

Rabbit
反应种属：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human SFRS15.
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
抗体亚型：

IgG
纯化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
产品提供形式：

Liquid
应用范围：

WB, IHC, ELISA
推荐稀释比：

Application Recommended Dilution

WB 1:500-1:2000

IHC 1:100-1:300

ELISA 1:40000
Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough.
基因功能参考文献：
1. Report frequency of SFRS15 SNPs in diabetic nephropathy. PMID: 24821155
2. Describes function of the CTD-interacting domain of human SCAF8, human SCAF4, and similar proteins in S. cerevisiae. PMID: 18550522
3. Describes identification of rat serine/arginine-rich splicing factors that interact with RNA polymerase II, including rA1, rA4, rA8, and rA9. PMID: 8692929
亚细胞定位：

Nucleus.
蛋白家族：

Splicing factor SR family
数据库链接：

HGNC: 19304

OMIM: 616023

KEGG: hsa:57466

STRING: 9606.ENSP00000286835

UniGene: Hs.17255