SAMSN1 Antibody, FITC conjugated

中文名称：

SAMSN1兔多克隆抗体, FITC偶联
货号：

CSB-PA885722LC01HU
规格：

￥880
其他：

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产品名称：

Rabbit anti-Homo sapiens (Human) SAMSN1 Polyclonal antibody
Uniprot No.：

Q9NSI8
基因名：

SAMSN1
别名：

HACS1 antibody; Hematopoietic adapter containing SH3 and sterile α, motif (SAM) domains 1 antibody; Hematopoietic adapter containing SH3 and sterile alpha motif (SAM) domains 1 antibody; Hematopoietic adaptor containing SH3 and SAM domains 1 antibody; Nash1 antibody; Nuclear localization signals SAM and SH3 domain containing 1 antibody; SAM and SH3 domain containing 2 antibody; SAM domain antibody; SAM domain containing protein SAMSN 1 antibody; SAM domain SH3 domain and nuclear localisation signals 1 antibody; SAM domain SH3 domain and nuclear localization signals 1 antibody; SAM domain, SH3 domain and nuclear localization signals protein 1 antibody; SAM domain-containing protein SAMSN-1 antibody; SAMN1_HUMAN antibody; SAMSN 1 antibody; Samsn1 antibody; SASH2 antibody; SH3 domain and nuclear localisation signals 1 antibody; SH3 domain and nuclear localization signals protein 1 antibody; SH3 SAM adaptor protein antibody; SH3-SAM adaptor protein antibody; SH3D6B antibody; SLy2 antibody; Src homology domain 3 (SH3) containing adapter protein SH3 lymphocyte protein 2 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human SAM domain-containing protein SAMSN-1 protein (1-373AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
基因功能参考文献：
1. Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma. PMID: 25805236
2. This is the first study to identify deletion of a key gene in the C57BL/KaLwRij mice that also displays reduced gene expression in patients with MM and is therefore likely to play an integral role in MM disease development. PMID: 25117979
3. High expression of SAMSN1 is a significant risk factor for the progression free and overall survival of glioblastoma multiforme PMID: 24278465
4. the immunoinhibitory roles of SLy2 in vivo and suggest that the physiological up-regulation of SLy2 observed upon B cell activation functions to counteract excessive B cell spreading. PMID: 21296879
5. In the nucleus, SLy2 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1. PMID: 20478393
6. HACS1 is up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. PMID: 15381729
7. downregulation of SAMSN1 gene in human lung cancer. PMID: 18523997
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亚细胞定位：

Nucleus. Cytoplasm. Cell projection, ruffle.
组织特异性：

Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.
数据库链接：

HGNC: 10528

OMIM: 607978

KEGG: hsa:64092

STRING: 9606.ENSP00000383411

UniGene: Hs.473341

SAMSN1 Antibody, FITC conjugated

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