SAA2 Antibody, FITC conjugated

1. The prevalence of the SAA2 polymorphisms (rs 2445174 and rs2468844) did not differ significantly between the groups of ankylosing spondylitis patients with and without amyloidosis. PMID: 26300108
2. successful quantification of SAA2 in crude serum by MRM, for the first time, shows that SAA2 can be a good biomarker for the detection of lung cancers. PMID: 22300576
3. The glucocorticoid response element of the SAA2 promoter is dysfunctional compared to that of SAA1, hence glucocorticoids are unable to enhance the cytokine-driven transcriptional activity of SAA2. PMID: 12077270
4. saa2 is regulated by tumor necrosis factor-alpha, interleukin-6, and glucocorticoids in hepatic and epithelial cells. PMID: 14871291
5. Increased expression of SAA2 by adipocytes in obesity may play a critical role in local and systemic inflammation and free fatty acid production and could be a direct link between obesity and its comorbidities. PMID: 16737350
6. CRP and SAA strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock. PMID: 18385816

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Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA2 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

Secreted.

SAA family

Expressed by the liver; secreted in plasma.

HGNC: 10514

OMIM: 104751

KEGG: hsa:6289

STRING: 9606.ENSP00000256733

UniGene: Hs.731376