RUSC1 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) RUSC1 Polyclonal antibody
Uniprot No.：

Q9BVN2
基因名：

RUSC1
别名：

RUSC1 antibody; NESCARUN and SH3 domain-containing protein 1 antibody; New molecule containing SH3 at the carboxy-terminus antibody; Nesca antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human RUN and SH3 domain-containing protein 1 protein (231-433AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth. May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.
基因功能参考文献：
1. RUN domain of NESCA can bind H-Ras, a downstream signaling molecule of TrkA, with high affinity. Moreover, NESCA RUN can directly interact with TrkA. PMID: 22821014
2. Nesca functions as an adapter involved in neuronal vesicular transport PMID: 22404429
3. Data show that NESCA and NEMO interact by their N-terminal region, that NESCA directly associates with TRAF6, which in turn catalyzes NESCA polyubiquitination, and that NESCA overexpression strongly inhibits TRAF6-mediated polyubiquitination of NEMO. PMID: 19365808
亚细胞定位：

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Early endosome. Cell junction, synapse, postsynaptic density. Golgi apparatus.
组织特异性：

Predominantly expressed in brain.
数据库链接：

HGNC: 17153

OMIM: 617318

KEGG: hsa:23623

STRING: 9606.ENSP00000357336

UniGene: Hs.226499