RUFY3 Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) RUFY3 Polyclonal antibody
Uniprot No.：

Q7L099
基因名：

RUFY3
别名：

Protein RUFY3 antibody; rap2 interacting protein x antibody; Rap2 interacting protein x isoform 2 antibody; Rap2-interacting protein x antibody; RIPx antibody; Rpipx antibody; Rufy3 antibody; RUFY3_HUMAN antibody; RUN and FYVE domain containing 3 antibody; Singar antibody; Singar1 antibody; Single axon regulated protein antibody; single axon related 1 antibody; Single axon-regulated protein antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Protein RUFY3 protein (243-352AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner.
基因功能参考文献：
1. these findings provide important evidence that PAK1 can positively regulate RUFY3 expression, which contribute to the metastatic potential of gastric cancer cells PMID: 25766321
2. Rab5(Q79L) interacts with the carboxyl terminus of RUFY3 PMID: 20376209
亚细胞定位：

Cytoplasm. Endomembrane system. Cell projection, invadopodium. Perikaryon. Cell projection. Cell projection, growth cone. Cell projection, filopodium. Cell projection, lamellipodium.
组织特异性：

Overexpressed in gastric cancer cells and tissues (at protein level).
数据库链接：

HGNC: 30285

OMIM: 611194

KEGG: hsa:22902

STRING: 9606.ENSP00000370394

UniGene: Hs.740904