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  4. RTN4RL2 Antibody, FITC conjugated

RTN4RL2 Antibody, FITC conjugated

说明书
  • 中文名称：
    RTN4RL2兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA774805NC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RTN4RL2 Polyclonal antibody
  • Uniprot No.：
    Q86UN3
  • 基因名：
    RTN4RL2
  • 别名：
    RTN4RL2 antibody; NGRH1 antibody; NGRL3 antibody; Reticulon-4 receptor-like 2 antibody; Nogo receptor-like 3 antibody; Nogo-66 receptor homolog 1 antibody; Nogo-66 receptor-related protein 2 antibody; NgR2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Reticulon-4 receptor-like 2 protein (355-372AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶点详情

  • 功能：
    Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton.
  • 基因功能参考文献：
    1. Authors highlight the structural and biochemical aspects of the interaction of Nogo receptors (R1 and R2) with myelin inhibitors such as MAG, Nogo A and OMgp.[Review] PMID: 24956133
    2. These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin. PMID: 21906273
    3. predominantly expressed in the neurons of the embryonic and adult nervous systems PMID: 14664809
    4. The release of N-terminal fragment-NgRH1 was blocked by a hydroxamate-based zinc metalloproteinase inhibitor and tissue inhibitor of metalloproteinases-2 and -3 PMID: 15629437
    5. Nogo-66 receptor homolog 1 signaling regulates activity-dependent synaptic strength and neuronal plasticity. PMID: 18337405

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Perikaryon. Cell projection, axon.
  • 蛋白家族：
    Nogo receptor family
  • 组织特异性：
    Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.
  • 数据库链接：

    HGNC: 23053

    OMIM: 610462

    KEGG: hsa:349667

    STRING: 9606.ENSP00000335397

    UniGene: Hs.502618

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