RTN4RL1 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) RTN4RL1 Polyclonal antibody
Uniprot No.：

Q86UN2
基因名：

RTN4RL1
别名：

DKFZp547J144 antibody; NgR 3 antibody; NgR3 antibody; NGRH 2 antibody; NGRH2 antibody; NGRL2 antibody; Nogo 66 receptor homolog 2 antibody; Nogo 66 receptor related protein 3 antibody; Nogo receptor like 2 antibody; Nogo receptor-like 2 antibody; Nogo-66 receptor homolog 2 antibody; Nogo-66 receptor-related protein 3 antibody; R4RL1_HUMAN antibody; Reticulon 4 receptor like 1 antibody; Reticulon-4 receptor-like 1 antibody; RTN4RL1 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Reticulon-4 receptor-like 1 protein (201-420AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton.
基因功能参考文献：
1. Duplication of 10q22.3-q23.3 encompassing NGR3 gene is associated with congenital heart disease, microcephaly, and mild intellectual disability PMID: 26383923
2. predominantly expressed in the neurons of the embryonic and adult nervous systems PMID: 14664809
亚细胞定位：

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Perikaryon. Cell projection.
蛋白家族：

Nogo receptor family
组织特异性：

Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.
数据库链接：

HGNC: 21329

OMIM: 610461

KEGG: hsa:146760

STRING: 9606.ENSP00000330631

UniGene: Hs.22917