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  4. RPRD1A Antibody, HRP conjugated

RPRD1A Antibody, HRP conjugated

说明书
  • 中文名称：
    RPRD1A兔多克隆抗体, HRP偶联
  • 货号：
    CSB-PA850404LB01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RPRD1A Polyclonal antibody
  • Uniprot No.：
    Q96P16
  • 基因名：
    RPRD1A
  • 别名：
    C77387 antibody; CDKN2B-related protein antibody; Cyclin dependent kinase 2B inhibitor related protein antibody; Cyclin dependent kinase inhibitor 2B related protein (p15INK4B related protein) antibody; Cyclin dependent kinase inhibitor 2B related protein antibody; Cyclin dependent kinase inhibitor related protein antibody; Cyclin-dependent kinase inhibitor 2B-related protein antibody; FLJ10656 antibody; HsT3101 antibody; Hypothetical protein FLJ10656 antibody; KIAA4077 antibody; MGC19513 antibody; MGC29396 antibody; MGC36325 antibody; mKIAA4077 antibody; p15INK4B related protein antibody; p15INK4B-related protein antibody; Putative uncharacterized protein P15RS antibody; Regulation of nuclear pre mRNA domain containing 1A antibody; Regulation of nuclear pre-mRNA domain-containing protein 1A antibody; RGD1307374 antibody; RPR1A_HUMAN antibody; RPRD1A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A protein (2-276AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    HRP
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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RPRD1A antibodies

RPRD1A Proteins

靶点详情

  • 功能：
    Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
  • 基因功能参考文献：
    1. Data suggest that p15RS (p15INK4b-related sequence) acts as an intrinsic transcriptional repressor for Wnt/beta-catenin-mediated gene transcription through recruiting HDAC2 histone deacetylase. PMID: 25697359
    2. RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2. PMID: 24997600
    3. The p15RS expression specifically downregulates the expression of cathepsin B and MMP-9 at RNA levels, which are known to promote cell invasion through degrading extracellular matrix proteins. PMID: 22580456
    4. p15RS inhibits Wnt signaling by interrupting beta-catenin.TCF4 complex formation and that Wnt signaling initiates downstream gene expression by removing p15RS from promoters. PMID: 20739273
    5. molecular cloning and characterization of P15RS, a novel P15(INK4b) related gene involved in G1/S progression PMID: 12470661

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  • 蛋白家族：
    UPF0400 (RTT103) family
  • 数据库链接：

    HGNC: 25560

    OMIM: 610347

    KEGG: hsa:55197

    STRING: 9606.ENSP00000349955

    UniGene: Hs.464912

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