RNF26 Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) RNF26 Polyclonal antibody
Uniprot No.：

Q9BY78
基因名：

RNF26
别名：

RNF26; E3 ubiquitin-protein ligase RNF26; RING finger protein 26
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase RNF26 protein (246-433AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
基因功能参考文献：
1. Study reveals the endoplasmic reticulum (ER)-located ubiquitin ligase Ring finger protein 26 (RNF26) as the global architect of the entire endosomal system, including the trans-Golgi network. PMID: 27368102
亚细胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
组织特异性：

Ubiquitous. Up-regulated in several cancer cell lines.
数据库链接：

HGNC: 14646

OMIM: 606130

KEGG: hsa:79102

UniGene: Hs.524084