RNASEH2C Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) RNASEH2C Polyclonal antibody
Uniprot No.：

Q8TDP1
基因名：

RNASEH2C
别名：

RNASEH2C antibody; AYP1 antibody; Ribonuclease H2 subunit C antibody; RNase H2 subunit C antibody; Aicardi-Goutieres syndrome 3 protein antibody; AGS3 antibody; RNase H1 small subunit antibody; Ribonuclease HI subunit C antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Ribonuclease H2 subunit C protein (1-164AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
基因功能参考文献：
1. This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2C in patients with Aicardi-Goutieres Syndrome. PMID: 27643693
2. Examination of the effect of several Aicardi-Goutieres Syndrome-related mutations in the C subunit of RNase H2. PMID: 19015152
3. Describes an RNASEH2C pseudogene that is located close to the SRY gene on chromosome Y. PMID: 8244390
相关疾病：

Aicardi-Goutieres syndrome 3 (AGS3)
亚细胞定位：

Nucleus.
蛋白家族：

RNase H2 subunit C family
组织特异性：

Widely expressed.
数据库链接：

HGNC: 24116

OMIM: 610329

KEGG: hsa:84153

STRING: 9606.ENSP00000308193

UniGene: Hs.718438