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  4. RBM45 Antibody, FITC conjugated

RBM45 Antibody, FITC conjugated

说明书
  • 中文名称：
    RBM45兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA814203LC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RBM45 Polyclonal antibody
  • Uniprot No.：
    Q8IUH3
  • 基因名：
    RBM45
  • 别名：
    Developmentally-regulated RNA-binding protein 1 antibody; DRB1 antibody; FLJ44612 antibody; MGC42237 antibody; Putative RNA binding protein RB 1 antibody; RB-1 antibody; RBM45 antibody; RBM45_HUMAN antibody; RNA-binding motif protein 45 antibody; RNA-binding protein 45 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human RNA-binding protein 45 protein (170-244AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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RBM45 antibodies

RBM45 Proteins

靶点详情

  • 功能：
    RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.
  • 基因功能参考文献：
    1. Results suggest that RBM45 serves as a negative regulator to prevent FUS-mediated excessive recruitment of HDAC1 to the sites of DNA damage. PMID: 29140459
    2. Analysis of the biological processes and pathways associated with RBM45-interacting proteins indicates enrichment for nuclear RNA processing/splicing via association with hnRNP proteins and cytoplasmic RNA translation via eiF2 and eiF4 pathways. PMID: 26979993
    3. using an in vitro cellular model, we demonstrated that Drb1 co-localizes with cytoplasmic aggregates mediated by TAR DNA-binding protein 43 PMID: 27226551
    4. RMB45 may function as a homo-oligomer and that its oligomerization contributes to ALS/FTLD RNA-binding protein aggregation. PMID: 26391765
    5. Data indicate that RNA binding protein RBM45/Kelch-like ECH-associated protein 1 (KEAP1) interactions in amyotrophic lateral sclerosis (ALS) spinal cord. PMID: 25939382
    6. This study demonistrated that RBM45 protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. PMID: 22993125
    7. a new member of RRM-type neural RNA-binding protein PMID: 12220514

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.
  • 数据库链接：

    HGNC: 24468

    OMIM: 608888

    KEGG: hsa:129831

    STRING: 9606.ENSP00000286070

    UniGene: Hs.377257

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