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  4. Phospho-KCNJ16 (S416) Antibody

Phospho-KCNJ16 (S416) Antibody

说明书
  • 中文名称：
    磷酸化-KCNJ16 (S416)兔多克隆抗体
  • 货号：
    CSB-PA006347
  • 规格：
    ￥1090
  • 其他：

产品详情

  • Uniprot No.：
    Q9Z307
  • 基因名：
    Kcnj16
  • 别名：
    Kcnj16 antibody; Inward rectifier potassium channel 16 antibody; Inward rectifier K(+) channel Kir5.1 antibody; Potassium channel antibody; inwardly rectifying subfamily J member 16 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human KIR5.1 around the phosphorylation site of S416.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
    Immunofluorescence (IF) Protocol
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

靶点详情

  • 功能：
    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
  • 基因功能参考文献：
    1. HNF1beta renal knockout mouse exhibits down-regulation of Kcnj16.Thus, HNF1beta is a transcriptional activator of Kcnj16. PMID: 28577853
    2. Down-regulation of Kir5.1 is associated with the decline in auditory function in aging mice. PMID: 27376812
    3. Kir5.1 is inhibited in cortical collecting duct cells by dopamine PMID: 23986512
    4. These results highlight the important role that Kir5.1 plays as a pH-sensitive regulator of salt transport in the DCT, and the implication of these results for the correct genetic diagnosis of renal tubulopathies is discussed. PMID: 21633011
    5. Kir5.1 may be involved in the response to hypercapnic acidosis PMID: 21047793

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Basolateral cell membrane.
  • 蛋白家族：
    Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ16 subfamily
  • 数据库链接：

    KEGG: mmu:16517

    STRING: 10090.ENSMUSP00000102246

    UniGene: Mm.30176

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