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  4. PSMD11 Antibody

PSMD11 Antibody

说明书
  • 中文名称：
    PSMD11兔多克隆抗体
  • 货号：
    CSB-PA00575A0Rb
  • 规格：
    ￥440
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA00575A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA00575A0Rb at dilution of 1:100
    • Immunofluorescence staining of MCF-7 cells with CSB-PA00575A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PSMD11 Polyclonal antibody
  • Uniprot No.：
    O00231
  • 基因名：
    PSMD11
  • 别名：
    26S proteasome non-ATPase regulatory subunit 11 antibody; 26S proteasome regulatory subunit 9 antibody; 26S proteasome regulatory subunit p44.5 antibody; 26S proteasome regulatory subunit RPN6 antibody; 26S proteasome regulatory subunit S9 antibody; MGC3844 antibody; p44.5 antibody; protease 26S, subunit, 9 antibody; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 antibody; proteasome 26S subunit, non-ATPase, 11 antibody; PSD11_HUMAN antibody; PSMD 11 antibody; PSMD11 antibody; Rpn6 antibody; S9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human 26S proteasome non-ATPase regulatory subunit 11 protein (2-422AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PSMD11 Antibody (CSB-PA00575A0Rb)，的标记方式是Non-conjugated。对于PSMD11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA00575B0Rb PSMD11 Antibody, HRP conjugated ELISA
    FITC CSB-PA00575C0Rb PSMD11 Antibody, FITC conjugated
    Biotin CSB-PA00575D0Rb PSMD11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
    Immunofluorescence (IF) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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PSMD11 antibodies

PSMD11 Proteins

靶点详情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
  • 基因功能参考文献：
    1. human embryonic stem cells (hESCs) exhibit high proteasome activity that is correlated with increased levels of the 19S proteasome subunit PSMD11 (known as RPN-6 in Caenorhabditis elegans) and a corresponding increased assembly of the 26S/30S proteasome PMID: 22972301
    2. AMP-activated protein kinase is able to interact physically with this subunit and modify its phosphorylation status. PMID: 19616115
    3. interaction with ubiquitinated NF-kappaB2/p100 PMID: 12185077
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol.
  • 蛋白家族：
    Proteasome subunit S9 family
  • 组织特异性：
    Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.
  • 数据库链接：

    HGNC: 9556

    OMIM: 604449

    KEGG: hsa:5717

    STRING: 9606.ENSP00000261712

    UniGene: Hs.443379

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