POU5F1B Antibody, HRP conjugated

中文名称：

POU5F1B兔多克隆抗体, HRP偶联
货号：

CSB-PA23129B0Rb
规格：

￥880
其他：

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产品名称：

Rabbit anti-Homo sapiens (Human) POU5F1B Polyclonal antibody
Uniprot No.：

Q06416
基因名：

POU5F1B
别名：

class 5 antibody; Octamer-binding protein 3-like antibody; Octamer-binding transcription factor 3-like antibody; OTF3C antibody; OTF3P1 antibody; P5F1B_HUMAN antibody; POU5F1B antibody; POU5F1P1 antibody; POU5FLC20 antibody; POU5FLC8 antibody; Putative POU domain antibody; Putative POU domain, class 5, transcription factor 1B antibody; transcription factor 1B antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Putative POU domain, class 5, transcription factor 1B protein (10-138AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Shows weak transcriptional activator activity.
基因功能参考文献：
1. Study shows that irrespective of tumor type or clinicopathological status, breast cancer cells expressed high levels of Oct3/4 at mRNA and protein levels. Further sequencing analysis show that breast tumors and MCF-7 cell line predominantly expressed transcripts of POU5F1B, an Oct4-like gene from chromosome 8 which possess 94% similitude with oct-4. PMID: 29620155
2. POU5F1B promotes hepatocellular carcinoma cell proliferation by activating AKT protein. PMID: 29454285
3. We identified eight specific CpG sites at 8q24, including six correlated sites in the POU5F1B gene, as well as two CpG sites in intergenic regions, whose DNA methylation levels were associated with prostate cancer risk. PMID: 28463958
4. The POU5F1B pseudogene is amplified and expressed at a high level in, as well as confers an aggressive phenotype on, GC, and that POU5F1B amplification is associated with a poor prognosis in GC patients. PMID: 24362523
5. POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy. PMID: 25046748
6. Association of rs7014346 in POU5F1P1, rs989902 in PTPN13, and rs7003146 in TCF7L2 with variations in the risk of breast cancer in a Chinese Han population. PMID: 24338422
7. Data suggest that expression of Oct4 and NANOG (Nanog homeobox protein) is up-regulated in visceral adipose tissue stem cells in type 2 diabetes as compared to control; expression is also up-regulated in hyperglycemic conditions. PMID: 23064289
8. Over-expression of POU5F1P1 in prostatic carcinoma in addition to its genomic location and the putative function of its gene product render POU5F1P1 a good candidate to harbour functional genetic variants which modulate prostatic cancer susceptibility. PMID: 20017164
9. that a putative POU5F1P1 protein is localized in the nucleus, acts as a transcriptional activator and regulates the expression in a similar way to the POU5F1 isoform 1 PMID: 18949397
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亚细胞定位：

Nucleus.
蛋白家族：

POU transcription factor family, Class-5 subfamily
组织特异性：

Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.
数据库链接：

HGNC: 9223

OMIM: 615739

KEGG: hsa:5462

STRING: 9606.ENSP00000375557

UniGene: Hs.450254

POU5F1B Antibody, HRP conjugated

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