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  4. POU3F2 Antibody, FITC conjugated

POU3F2 Antibody, FITC conjugated

说明书
  • 中文名称：
    POU3F2兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA018397HC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) POU3F2 Polyclonal antibody
  • Uniprot No.：
    P20265
  • 基因名：
    POU3F2
  • 别名：
    Brain 2 antibody; Brain specific homeobox/POU domain protein 2 antibody; Brain-2 antibody; Brain-specific homeobox/POU domain protein 2 antibody; BRN 2 antibody; Brn-2 antibody; BRN2 antibody; N Oct 3 antibody; N OCT 3 Gene antibody; N Oct3 antibody; Nervous system specific octamer binding transcription factor antibody; Nervous system-specific octamer-binding transcription factor N-Oct-3 antibody; OCT 7 antibody; Oct-7 antibody; OCT7 antibody; Octamer Binding Transcription Factor 7 antibody; Octamer-binding protein 7 antibody; Octamer-binding transcription factor 7 antibody; OTF 7 antibody; OTF-7 antibody; OTF7 antibody; PO3F2_HUMAN antibody; POU class 3 homeobox 2, antibody; POU domain class 3 transcription factor 2 antibody; POU domain, class 3, transcription factor 2 antibody; Pou3f2 antibody; POUF 3 antibody; POUF3 antibody; Protein Brn 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human POU domain, class 3, transcription factor 2 protein (1-443AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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POU3F2 antibodies

POU3F2 Proteins

靶点详情

  • 功能：
    Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes.
  • 基因功能参考文献：
    1. Re4sults show that BRN2 is: directly transcriptionally repressed by AR, required for the expression of terminal neuroendocrine markers and aggressive growth of castration-resistant prostate cancer (CRPC), and is highly expressed in human neuroendocrine prostate cancer and metastatic CRPC with low circulating PSA. PMID: 27784708
    2. These findings not only shed light on the molecular mechanism of the anticancer properties of capsaicin, but also the transcription regulation of tNOX expression that may potentially explain how POU3F2 is associated with tumorigenesis. PMID: 27271588
    3. We show that POU3F2 lies downstreamof SIM1 and controls oxytocin expression in the hypothalamic neuroendocrine preoptic area. We show that this finding is consistent with the expression patterns of POU3F2 and related genes in the human brain. PMID: 26833329
    4. TTF1 expression in small-cell lung cancer is a cell lineage-specific phenomenon that involves the developing neural cell-specific homeoprotein BRN2. PMID: 23358112
    5. The present study investigated transcriptional regulation of CDH13 in melanoma. Found an inverse correlation between BRN2 and T-cadherin protein and transcript expression in melanoma. PMID: 23069940
    6. links BRN2 as an activator and MITF as a repressor of the NOTCH pathway in melanoma cells. Loss of the BRN2-MITF axis in antisense-ablated cell lines decreased the melanoma sphere-forming capability and cell adhesion PMID: 21358674
    7. a model for the apparent non-overlapping expression levels of BRN2 and MITF in melanoma, mediated by miR-211 expression. PMID: 21435193
    8. POU3F2 may regulate the properties of melanoma cells via autocrine KIT ligand signalling. PMID: 20337985
    9. The results suggest that the high levels of Brn-2 expression observed in melanomas link BRAF signaling to increased proliferation. PMID: 15024080
    10. Rb induces a proliferative arrest and regulates Brn-2 expression in retinoblastoma cells PMID: 17163992
    11. Brn-2 regulates invasiveness and directly represses Mitf expression. PMID: 18829533
    12. SOX9 and SOX10 but not BRN2 seem to be required for nestin expression in human melanoma. PMID: 18923447
    13. Expression and purification of full-length BRN2, a transcription factor involved in melanoma growth, are reported. PMID: 18996486

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    POU transcription factor family, Class-3 subfamily
  • 组织特异性：
    Expressed specifically in the neuroectodermal cell lineage.
  • 数据库链接：

    HGNC: 9215

    OMIM: 600494

    KEGG: hsa:5454

    STRING: 9606.ENSP00000329170

    UniGene: Hs.182505

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