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  4. PDE11A Antibody

PDE11A Antibody

说明书
  • 中文名称：
    PDE11A兔多克隆抗体
  • 货号：
    CSB-PA875726LA01HU
  • 规格：
    ￥440
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA875726LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA875726LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA875726LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDE11A Polyclonal antibody
  • Uniprot No.：
    Q9HCR9
  • 基因名：
    PDE11A
  • 别名：
    5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody; cAMP and cGMP phosphodiesterase 11A antibody; cGMP phosphodiesterase 11A antibody; Cyclic nucleotide phosphodiesterase 11A antibody; Dual 3'' antibody; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody; pde11 antibody; PDE11_HUMAN antibody; pde11a antibody; PDE11A1 antibody; pde11a2 antibody; Phosphodiesterase 11A antibody; PPNAD2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A protein (42-190AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDE11A Antibody (CSB-PA875726LA01HU)，的标记方式是Non-conjugated。对于PDE11A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA875726LB01HU PDE11A Antibody, HRP conjugated ELISA
    FITC CSB-PA875726LC01HU PDE11A Antibody, FITC conjugated
    Biotin CSB-PA875726LD01HU PDE11A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
    Immunofluorescence (IF) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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PDE11A antibodies

PDE11A Proteins

靶点详情

  • 功能：
    Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
  • 基因功能参考文献：
    1. One percent of the Swedish population carries a PDE11A loss-of-function mutation which is associated with elevated BP, abdominal obesity, and risk of ischemic stroke. PMID: 26820475
    2. Testicular germ cell tumors had 55 PDE11A variants: 20 missense (10 new, 9 in transcript variant 4, 1 in transcript variant 3), 4 splice-site, 2 nonsense, 7 synonymous, and 22 intronic. p.F258Y, p.G291R, p.V820M, p.R545X, and p.K568R were only in cases. PMID: 26459559
    3. PDE11A genetic variants may increase predisposition to ACTH-independent macronodular adrenal hyperplasia. PMID: 22996146
    4. found in single nerve trunks in the clitoral stroma PMID: 21697861
    5. Our data suggest that, like in the adrenal cortex and the testicular germ cells, PDE11A-inactivating genetic alterations may play a role in susceptibility to prostate cancer PMID: 20881257
    6. We demonstrate, in a large cohort of Carney Complex patients, a high frequency of PDE11A variants, suggesting that PDE11A is a genetic modifying factor for the development of testicular and adrenal tumors in patients with germline PRKAR1A mutation. PMID: 21047926
    7. PDE11A SNP assocaited with allergic asthma. PMID: 20920776
    8. we detected protein corresponding to PDE11A4, in human prostate, pituitary, heart and liver PMID: 15800651
    9. PDE11A genetic defects may be associated with adrenal pathology in a wider than previously suspected and is associated with adrenal hyperplasia and adenomas. PMID: 17178847
    10. Variants in PDE11A are not associated with citalopram response in patient with depression. PMID: 18043711
    11. N-terminal modifications strongly affect cGMP regulation of hPDE11A4 PMID: 18312413
    12. PDE11A is expressed widely in adrenal cortex. Its expression appears to be increased in PPNAD but varies widely among other adrenocortical tumors. PMID: 18491255
    13. PDE11A sequence defects predispose to a variety of lesions (beyond micronodular adrenocortical hyperplasia). PMID: 18559625
    14. PDE11A, is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142
    15. PDE11A-inactivating sequence variants may modify the risk of familial and bilateral testicular germ cell tumors. PMID: 19549888
    16. Immunohistochemistry revealed PDE11A expression higher in somatotropinomas than in normal somatotrophs, without significant difference between tumors with or without PDE11A variants. PMID: 19671705

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  • 相关疾病：
    Primary pigmented nodular adrenocortical disease 2 (PPNAD2)
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family
  • 组织特异性：
    Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is ex
  • 数据库链接：

    HGNC: 8773

    OMIM: 604961

    KEGG: hsa:50940

    STRING: 9606.ENSP00000286063

    UniGene: Hs.570273

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