PCSK2 Antibody, Biotin conjugated

1. PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes. PMID: 26607656
2. FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing. PMID: 25811241
3. in the processing of hypothalamic neuropeptides in huntington disease may partially arise from decreased PC1/3 and PC2 expressions. PMID: 24226266
4. variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin secretion, but also with lower glucagon levels, which could potentially counteract the effects of decreased insulin secretion on the risk of type 2 diabetes PMID: 23011353
5. The association of risk allele rs2021785 at PCSK2 with type 2 diabetes exists in a Han Chinese population PMID: 21437630
6. differential gene expression profiles revealed more abundant mRNA expression in ectopic ACTH syndrome than in Cushing disease of proprotein convertase-2 PMID: 21383526
7. PC1/3 governs the endocrine, and PC2 the neuronal processing, of proCCK, whereas PC5/6 contributes only to a modest endocrine synthesis of CCK-22. PMID: 18096669
8. SEMA3F, CLEC16A, LAMA3, and PCSK2 variants have roles in myocardial infarction in Japanese individuals PMID: 20036365
9. A marked decrease in the ratio of the PC2 precursor to the total enzymatic pool is observed in the frontal cortex of Alzheimer patients; however, the content and enzymatic activity of the PC2 mature form are similar in Alzheimer patients and controls. PMID: 14614908
10. concluded that there are two novel TRE-like sequences in the hPC2 promoter and that these regions act in concert in a unique manner to facilitate the effects of thyroid hormone and 9-cis-retinoic acid on PC2 PMID: 15585599
11. Single nucleotide polymorphisms in PCSK2 is associated with type 2 diabetes PMID: 17618154

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HGNC: 8744

OMIM: 162151

KEGG: hsa:5126

STRING: 9606.ENSP00000262545

UniGene: Hs.315186