PAH1 Antibody

1. Site-specific mutational analyses of the conserved residues within WRDPLVDID indicated that Trp-637 plays a crucial role in Pah1 function. This work also demonstrated that the catalytic activity of Pah1 is required but is not sufficient for its in vivo functions PMID: 29066621
2. These results suggest that Pah1p plays an important role in vacuolar activity by negatively regulating the expression of V-ATPase genes. As such, we provide evidence to show the role of Pah1p in vacuolar acidification and fragmentation. PMID: 28756231
3. The expression of Pah1 with combined mutations of S705D and 7A, which mimic its phosphorylation by CKII and lack of phosphorylation by Pho85-Pho80, caused an increase in triacylglycerol content and lipid droplet number in cells expressing the Nem1-Spo7 phosphatase complex. PMID: 27044741
4. shortened chronological life span of the pah1Delta mutant along with its growth defect on non-fermentable carbon sources and hypersensitivity to hydrogen peroxide was suppressed by the loss of Dgk1 diacylglycerol kinase PMID: 26338708
5. proteolysis of Pah1 by the 20S proteasome is controlled by its phosphorylation state PMID: 25809482
6. Report functional conservation of PAP1 between yeast and human. PMID: 25475986
7. essential role of PAH1 in triacylglycerol synthesis throughout growth PMID: 24196957
8. Phosphorylation/dephosphorylation is a major mechanism by which Pah1p PAP activity is regulated. (Review) PMID: 22910056
9. Pah1p and PA phosphatase activity are critical for vacuole homeostasis and fusion. PMID: 22121197
10. the expression of PAH1-encoded phosphatidate phosphatase was induced by zinc deficiency. PMID: 22128164
11. Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast PMID: 21708942
12. Data suggest that diacylglycerol generated by Pah1p is important for lipid droplet biogenesis. PMID: 21422231
13. Dephosphorylation of Pah1p by the Nem1p-Spo7p complex enables the amphipathic helix to anchor Pah1p onto the nuclear/ER membrane allowing the production of diacylglycerol for lipid biosynthesis. PMID: 20876142
14. Smp2 associates with the promoters of phospholipid biosynthetic enzymes in a Nem1-Spo7-dependent manner. Smp2 is a critical factor in coordinating phospholipid biosynthesis at the nuclear/ER membrane with nuclear growth during the cell cycle. PMID: 15889145
15. reports for the first time the identification of the S. cerevisiae PAH1 (previously known as SMP2) gene encoding a Mg2+-dependent PA phosphatase enzyme PMID: 16467296
16. PAP1 activity of the PAH1 gene product is essential for its roles in lipid metabolism and cell physiology. PMID: 17971454

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KEGG: sce:YMR165C

STRING: 4932.YMR165C