ORMDL1 Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) ORMDL1 Polyclonal antibody
Uniprot No.：

Q9P0S3
基因名：

ORMDL1
别名：

ORMDL1; HSPC202; ORM1-like protein 1; Adoplin-1
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human ORM1-like protein 1 protein (48-100AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Negative regulator of sphingolipid synthesis.
基因功能参考文献：
1. ORMDL1 downregulation modestly increased levels of sphingosine, S1P, and ceramide in HepG2 cells. PMID: 27313060
2. Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells. PMID: 25395622
3. ORMDL1, ORMDL2 and ORMDL3 mediate the feedback response in ceramide biosynthesis. PMID: 23066021
4. Adoplin-1/ORMDL-1 displays reduced expression in association with presenilin mutations; Adoplin-1 & two highly homologous genes (adoplin-2, -3) are a gene family that encodes transmembrane proteins that may play roles in gamma-secretase complex maturation PMID: 17928364
亚细胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

ORM family
组织特异性：

Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. Expressed at intermediate level in pancreas, placenta and brain but low in skele
数据库链接：

HGNC: 16036

OMIM: 610073

KEGG: hsa:94101

STRING: 9606.ENSP00000326869

UniGene: Hs.700632