NSUN4 Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) NSUN4 Polyclonal antibody
Uniprot No.：

Q96CB9
基因名：

NSUN4
别名：

5 methylcytosine rRNA methyltransferase NSUN4 antibody; EC=2.1.1.- antibody; NOL1/NOP2/Sun domain family member 4 antibody; NOL1/NOP2/Sun domain family, member 4 antibody; NOP2/Sun domain family, member 4 antibody; Nsun4 antibody; NSUN4_HUMAN antibody; Putative methyltransferase NSUN4 antibody; RP4-603I14.2 antibody; Shtap antibody; Sperm head and tail associated protein antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human 5-methylcytosine rRNA methyltransferase NSUN4 protein (26-284AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.
基因功能参考文献：
1. It involves in epigenetic changes during the progression of Alzheimer disease pathology. PMID: 24387984
2. analysis of the 3D crystal structure of the human MTERF4-NSUN4 complex PMID: 22949673
3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19086053
亚细胞定位：

Mitochondrion.
蛋白家族：

Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family
数据库链接：

HGNC: 31802

OMIM: 615394

KEGG: hsa:387338

STRING: 9606.ENSP00000419740

UniGene: Hs.163424