NSMAF Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) NSMAF Polyclonal antibody
Uniprot No.：

Q92636
基因名：

NSMAF
别名：

NSMAF antibody; FANProtein FAN antibody; Factor associated with neutral sphingomyelinase activation antibody; Factor associated with N-SMase activation antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Protein FAN protein (1-233AA )
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
基因功能参考文献：
1. these data identify a novel caspase-2-interacting factor, FAN, and expand the role for the enzyme in seemingly non-apoptotic cellular mechanisms. PMID: 29621545
2. The rs1050504 C > T genotype was observed to be significantly associated with an increased risk for developing pulmonary tuberculosis. PMID: 29115933
3. The interaction of FAN with receptor for activated C-kinase 1 (RACK1) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN. PMID: 12391233
4. sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase PMID: 15653433
5. Regulation of NSMAF by TNF-alpha involves PRKCD in lung epithelial cells. PMID: 18653803
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组织特异性：

Ubiquitous.
数据库链接：

HGNC: 8017

OMIM: 603043

KEGG: hsa:8439

STRING: 9606.ENSP00000411012

UniGene: Hs.372000