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  4. NPRL3 Antibody, FITC conjugated

NPRL3 Antibody, FITC conjugated

说明书
  • 中文名称：
    NPRL3兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA619643LC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NPRL3 Polyclonal antibody
  • Uniprot No.：
    Q12980
  • 基因名：
    NPRL3
  • 别名：
    otein antibody; Alpha-globin regulatory element-containing gene protein antibody; C16ORF35 antibody; CGTHBA antibody; Conserved gene telomeric to alpha globin cluster antibody; HS 40 antibody; MARE antibody; Nitrogen permease regulator 3-like protein antibody; Nitrogen permease regulator-like 3 (S. cerevisiae) antibody; NPR3 antibody; NPRL3 antibody; NPRL3_HUMAN antibody; Protein CGTHBA antibody; RMD11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human GATOR complex protein NPRL3 protein (349-482AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NPRL3 antibodies

NPRL3 Proteins

靶点详情

  • 功能：
    As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
  • 基因功能参考文献：
    1. This study demonstrated that mutation of NPRL3 in familial focal epilepsies and focal cortical dysplasia. PMID: 27173016
    2. NPRL3 mutations are significant cause of focal epilepsy. PMID: 26505888
    3. Mutations in NPRL3 are a novel cause of familial cortical dysplasia. PMID: 26285051
    4. NPRL3 is a candidate gene for harbouring mutations in individuals with developmental abnormalities of the cardiovascular system. PMID: 22538705
    5. NPRL3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    6. C16orf35 can modulate differentially the specific activities of selected p73 isoforms. PMID: 19666006

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  • 相关疾病：
    Epilepsy, familial focal, with variable foci 3 (FFEVF3)
  • 亚细胞定位：
    Lysosome membrane.
  • 蛋白家族：
    NPR3 family
  • 组织特异性：
    Widely expressed. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes.
  • 数据库链接：

    HGNC: 14124

    OMIM: 600928

    KEGG: hsa:8131

    STRING: 9606.ENSP00000382834

    UniGene: Hs.19699

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