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  4. NOXO1 Antibody, Biotin conjugated

NOXO1 Antibody, Biotin conjugated

说明书
  • 中文名称：
    NOXO1兔多克隆抗体, Biotin偶联
  • 货号：
    CSB-PA015964LD01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NOXO1 Polyclonal antibody
  • Uniprot No.：
    Q8NFA2
  • 基因名：
    NOXO1
  • 别名：
    NADPH oxidase organizer 1 antibody; NADPH oxidase regulatory protein antibody; Nox organizer 1 antibody; Nox organizing protein 1 antibody; Nox-organizing protein 1 antibody; NOXO1 antibody; NOXO1_HUMAN antibody; P41NOX antibody; Regulatory protein P41NOX antibody; SH3 and PX domain-containing protein 5 antibody; SH3PXD5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human NADPH oxidase organizer 1 protein (304-376AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Biotin
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NOXO1 antibodies

NOXO1 Proteins

靶点详情

  • 功能：
    Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
  • 基因功能参考文献：
    1. PEDF protects human glomerular mesangial cells from diabetes-derived oxidative stress via NOXO1- iNOS suppression. PMID: 28944893
    2. Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region. PMID: 28625920
    3. TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. PMID: 23975421
    4. Phosphorylation of Thr341 allows Noxo1 to sufficiently interact with Noxa1, an interaction that participates in Nox1 activation PMID: 23957209
    5. Phorbol myristate acetate stimulates NOXO1 phosphorylation in a transfected human embryonic kidney (HEK) 293 epithelial cell model via protein kinase C and identify Ser-154 as the major phosphorylated site. PMID: 23322165
    6. Surface plasmon resonance experiments identify PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as preferred targets of NOXO1beta PX. PMID: 22342885
    7. The backbone assignments of NOXO1beta PX are studied using NMR. PMID: 21188560
    8. The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented. PMID: 20454568
    9. NOXO1 and NOXA1 activate Nox1 without the need for agonist activation, and this is mediated in part by binding of the NOXO1 PX domain to membrane lipids. PMID: 14617635
    10. NOXO1, p47phox, and p67phox regulate Nox3 PMID: 15181005
    11. Data suggest different tissue localizations and functions for NOXO1beta and NOXO1gamma in regulating Nox family members. PMID: 15949904
    12. These results suggest that the formation of the complex consisting of Nox1, betaPix, and NoxO1 is likely to be a critical step in EGF-induced ROS generation. PMID: 16329988
    13. This study shows the expression of alternatively spliced transcripts of the NOXO1 gene and the roles of the protein products in the activation of Nox oxidases. PMID: 16911517
    14. These findings suggest that Nox activation involves a conformational change leading to disruption of the bis-SH3-PRR interaction in Noxo1. PMID: 17126813

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  • 亚细胞定位：
    [Isoform 3]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910).
  • 组织特异性：
    Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
  • 数据库链接：

    HGNC: 19404

    OMIM: 611256

    KEGG: hsa:124056

    STRING: 9606.ENSP00000380450

    UniGene: Hs.191762

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