NKX2-3 Antibody, FITC conjugated

1. Studies suggest oncogenic NK2 homeobox 3 homeobox protein (NKX2-3) in lymphomagenesis, and show a mouse model for studying the biology and therapy of human marginal-zone B-cell lymphomas. PMID: 27297662
2. NKX2-3 is a key mediator for maintaining myofibroblast characteristics, and our results show that colorectal myofibroblasts, as defined by the expression of AOC3, NKX2-3, and other markers, are a distinctly different cell type from TGFbeta-activated fibroblasts PMID: 27036009
3. The persons with a NKX2-3 G or T allele may have a moderately increased risk of CD. PMID: 24473197
4. NKX2-3 may play different roles in ulcerative colitis and Crohn's disease pathogenesis by differential regulation of EGR1. PMID: 21968973
5. A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both Crohn's disease and ulcerative colitis patients. PMID: 22377701
6. The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by chromatin immunoprecipitation assay. PMID: 21803625
7. the risk haplotype of NKX2.3 confers susceptibility to UC through increasing expression of NKX2.3 mRNA in the colonic mucosa. PMID: 21514341
8. NKX2-3 may play an important role in inflammatory bowel disease pathogenesis by regulating endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells. PMID: 21637825
9. Data suggest that NKX2-3 and IRGM are susceptibility loci for inflammatory bowel disease in Eastern European patients. PMID: 21049557
10. Nkx2-3 may contribute to the pathogenesis of inflammatory bowel disease-associated colorectal cancer and sporadic colorectal cancer by regulating the Wnt signaling pathway. PMID: 20165982
11. a decrease in Nkx2-3 gene expression level can profoundly alter the expression of genes and cellular functions relevant to the pathogenesis and progression of inflammatory bowel disease, such as EDN1. PMID: 20188614
12. Single nucleotide polymorphism in NKX2-3 gene is associated with Crohn's disease and ulcerative colitis PMID: 18438405
13. A positive association signal presumably common to different ethnic groups for rs10883365 was detected in the upstream region of NKX2-3. PMID: 18936107

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HGNC: 7836

OMIM: 606727

KEGG: hsa:159296

STRING: 9606.ENSP00000342828

UniGene: Hs.243272