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  4. NKIRAS1 Antibody, Biotin conjugated

NKIRAS1 Antibody, Biotin conjugated

说明书
  • 中文名称：
    NKIRAS1兔多克隆抗体, Biotin偶联
  • 货号：
    CSB-PA885767LD01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NKIRAS1 Polyclonal antibody
  • Uniprot No.：
    Q9NYS0
  • 基因名：
    NKIRAS1
  • 别名：
    2400004O09Rik antibody; I kappa B interacting Ras like protein 1 antibody; I-kappa-B-interacting Ras-like protein 1 antibody; Kappa B Ras 1 antibody; Kappa B Ras protein 1 antibody; Kappa B-Ras protein 1 antibody; KappaB Ras1 antibody; KappaB-Ras1 antibody; KBRAS 1 antibody; KBRAS1 antibody; KBRS1_HUMAN antibody; NF kappa B inhibitor interacting Ras like protein 1 antibody; NF-kappa-B inhibitor-interacting Ras-like protein 1 antibody; NFKB inhibitor interacting Ras like 1 antibody; NFKB inhibitor interacting Ras like protein 1 antibody; NKIRAS 1 antibody; nkiras1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 1 protein (1-192AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Biotin
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NKIRAS1 antibodies

NKIRAS1 Proteins

靶点详情

  • 功能：
    Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
  • 基因功能参考文献：
    1. It was demonstrated that elevated levels of mRNA for NKIRAS1 was significantly associated both with loss of methylation in NKIRAS1 CpG-islands and methylation in a number of miRNA genes. PMID: 25869366
    2. Significant correlation was found between alterations of methylation status of miR-34b/c, miR-193a and the expression level of NKIRAS1 target gene in the primary lung tumors. PMID: 23156677
    3. Low kappaB-Ras1 expression is associated with gliomas. PMID: 21302000
    4. It was shown the decreased expression level of NKIRAS1 in Renal cell carcinoma PMID: 20693965
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Small GTPase superfamily, Ras family, KappaB-Ras subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 17899

    OMIM: 604496

    KEGG: hsa:28512

    STRING: 9606.ENSP00000373411

    UniGene: Hs.173202

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