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  4. NDC1 Antibody, HRP conjugated

NDC1 Antibody, HRP conjugated

说明书
  • 中文名称：
    NDC1兔多克隆抗体, HRP偶联
  • 货号：
    CSB-PA874808LB01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NDC1 Polyclonal antibody
  • Uniprot No.：
    Q9BTX1
  • 基因名：
    NDC1
  • 别名：
    NDC1; TMEM48; Nucleoporin NDC1; hNDC1; Transmembrane protein 48
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nucleoporin NDC1 protein (385-517AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    HRP
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NDC1 antibodies

NDC1 Proteins

靶点详情

  • 功能：
    Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
  • 基因功能参考文献：
    1. miR-421 can suppress TMEM48 so that leads the non-small cancer cell lines (A549) to apoptosis. PMID: 29906465
    2. In mature human spermatozoa, SEPT12 and NDC1 are majorly colocalized in the centrosome regions; however, NDC1 is only slightly co-expressed with SEPT12 at the annulus of the sperm tail. PMID: 27854341
    3. The biological relevance of TMEM48 in NSCLC progression. PMID: 26392108
    4. Human homologue NDC1/NET3 contains three FG repeats in the C-terminus, a feature of many nuclear pore proteins. PMID: 16779818
    5. NDC1-mediated localization of ALADIN to nuclear pore complexes is essential for selective nuclear protein import; abrogation of the interaction between ALADIN and NDC1 may be important for the development of triple-A syndrome. PMID: 19703420
    6. ALADIN is anchored in the nuclear envelope via NDC1 and that this interaction gets lost, if ALADIN is mutated. PMID: 19782045

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  • 亚细胞定位：
    Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.
  • 蛋白家族：
    NDC1 family
  • 数据库链接：

    HGNC: 25525

    OMIM: 610115

    KEGG: hsa:55706

    STRING: 9606.ENSP00000360483

    UniGene: Hs.476525

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