NCOA5 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) NCOA5 Polyclonal antibody
Uniprot No.：

Q9HCD5
基因名：

NCOA5
别名：

NCOA5 antibody; KIAA1637 antibody; Nuclear receptor coactivator 5 antibody; NCoA-5 antibody; Coactivator independent of AF-2 antibody; CIA antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Nuclear receptor coactivator 5 protein (112-283AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
基因功能参考文献：
1. knockout of NCOA5 can suppress the epithelial - mesenchymal transition (EMT) in hepatocellular carcinoma cells. PMID: 29626478
2. This study provides new insights and evidences that NOCA5 over-expression was significantly correlated with progression and prognosis in luminal breast cancer. However, the precise cellular mechanisms for NOCA5 in luminal breast cancer need to be further explored. PMID: 27847318
3. NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma. PMID: 25416054
4. suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 deficiency increases susceptibility to both glucose intolerance and HCC, partially by increasing IL-6 expression PMID: 24332041
5. gene polymorphism confers susceptibility to psoriasis in a Southern European population PMID: 21645569
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亚细胞定位：

Nucleus.
组织特异性：

Widely expressed.
数据库链接：

HGNC: 15909

KEGG: hsa:57727

STRING: 9606.ENSP00000290231

UniGene: Hs.654991