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NCKIPSD Antibody

说明书
  • 中文名称：
    NCKIPSD兔多克隆抗体
  • 货号：
    CSB-PA015534GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NZQ3
  • 基因名：
    NCKIPSD
  • 别名：
    54 kDa VacA-interacting protein antibody; 54 kDa vimentin-interacting protein antibody; 90 kDa SH3 protein interacting with Nck antibody; AF3p21 antibody; dia interacting protein antibody; Dia-interacting protein 1 antibody; Diaphanous protein-interacting protein antibody; DIP antibody; DIP-1 antibody; DIP1 antibody; NCK interacting protein with SH3 domain antibody; NCK-interacting protein with SH3 domain antibody; Nckipsd antibody; ORF1 antibody; SH3 adapter protein SPIN90 antibody; SH3 protein interacting with Nck 90 kDa antibody; SPIN90 antibody; SPN90_HUMAN antibody; VIP54 antibody; WASLBP antibody; WASP-interacting SH3-domain protein antibody; WISH antibody; wiskott- Aldrich syndrome protein-interacting protein antibody; Wiskott-Aldrich syndrome protein-interacting protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NCKIPSD
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NCKIPSD Proteins

靶点详情

  • 功能：
    Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.
  • 基因功能参考文献：
    1. Low SPIN90 expression is associated with Breast Cancer. PMID: 28652253
    2. findings suggest that SPIN90 contributes to the formation and movement of endosomal vesicles, and modulates the stability of EGFR protein, which affects cell cycle progression PMID: 24340049
    3. SPIN90 dephosphorylation is a prerequisite step for releasing cofilin so that cofilin can adequately sever actin filaments into monomeric form. PMID: 23765104
    4. Findings show that SPIN90 modulates synaptic activity in neurons as a result of its phosphorylation. PMID: 23342115
    5. Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation. PMID: 23024796
    6. the interaction of the betaPIX.WASP.SPIN90 complex with Nck is crucial for stable cell adhesion and can be dynamically modulated by SPIN90 phosphorylation that is dependent on cell adhesion and ERK activation PMID: 14559906
    7. SPIN90 participates in reorganization of the actin cytoskeleton and in actin-based cell motility PMID: 16253999
    8. These observations point to a pivotal role for DIP in the control of nonbranched and branched actin-filament assembly that is mediated by Diaphanous-related formins and activators of Arp2/3, respectively. PMID: 17398099
    9. DIP binds to and inhibits actin assembly by the FH2 domain of the formin mDia2 PMID: 17398099

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  • 相关疾病：
    A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with KMT2A/MLL1.
  • 亚细胞定位：
    Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
  • 组织特异性：
    Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen.
  • 数据库链接：

    HGNC: 15486

    OMIM: 606671

    KEGG: hsa:51517

    STRING: 9606.ENSP00000294129

    UniGene: Hs.655006

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