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  4. NAPRT Antibody, FITC conjugated

NAPRT Antibody, FITC conjugated

说明书
  • 中文名称：
    NAPRT兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA015451EC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NAPRT Polyclonal antibody
  • Uniprot No.：
    Q6XQN6
  • 基因名：
    NAPRT
  • 别名：
    FHA HIT interacting protein antibody; FHA-HIT-interacting protein antibody; FHIP antibody; NAPRT1 antibody; NAPRTase antibody; Nicotinate phosphoribosyltransferase antibody; Nicotinate phosphoribosyltransferase domain containing 1 antibody; Nicotinate phosphoribosyltransferase domain-containing protein 1 antibody; Nicotinic acid phosphoribosyltransferase antibody; PNCB_HUMAN antibody; PP3856 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nicotinate phosphoribosyltransferase protein (1-310AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NAPRT antibodies

NAPRT Proteins

靶点详情

  • 功能：
    Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
  • 基因功能参考文献：
    1. No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma PMID: 28860121
    2. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases PMID: 28416276
    3. High NAPRTase expression is associated with neoplasms. PMID: 26675378
    4. Tumor-specific promoter hypermethylation of NAPRT1 inactivates one of two NAD salvage pathways, resulting in synthetic lethality with the coadministration of a NAMPT inhibitor. PMID: 24097869
    5. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner PMID: 22570471
    6. NAPRT expression was varied in lymphomas with 30-50% low expression except for Hodgkin's lymphoma where 85% displayed low expression PMID: 21492230
    7. NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD PMID: 17604275

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  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    NAPRTase family
  • 数据库链接：

    HGNC: 30450

    OMIM: 611552

    KEGG: hsa:93100

    STRING: 9606.ENSP00000401508

    UniGene: Hs.493164

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