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  4. MYT1 Antibody, FITC conjugated

MYT1 Antibody, FITC conjugated

说明书
  • 中文名称：
    MYT1兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA015387LC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MYT1 Polyclonal antibody
  • Uniprot No.：
    Q01538
  • 基因名：
    MYT1
  • 别名：
    C20orf36 antibody; KIAA0835 antibody; KIAA1050 antibody; MTF1 antibody; Myelin transcription factor 1 antibody; Myelin transcription factor I antibody; MYT1 antibody; MYT1_HUMAN antibody; MyTI antibody; PLPB1 antibody; Proteolipid protein-binding protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Myelin transcription factor 1 protein (317-451AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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MYT1 antibodies

MYT1 Proteins

靶点详情

  • 功能：
    Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
  • 基因功能参考文献：
    1. A novel missense variant affecting function, c.323C>T (p.(Ser108Leu)), was identified in MYT1, in a patient presenting with a severe form of OAVS. MYT1 overexpression downregulated all RA receptors genes in vitro. PMID: 28612832
    2. although depletion of MYT1 alone did not affect long-term cell growth, it potentiated with DNA damage to inhibit cell growth in clonogenic survival and tumor xenograft models PMID: 23146904
    3. present in brain in infancy and prenatally in infants with periventricular leukomalacia PMID: 12524179
    4. These results suggesta potential role for Myt1 in the regeneration of oligodendrocyte lineage cells in response to demyelination. PMID: 17330875
    5. UVA-induced caspase-3 cleavage and DNA fragmentation were suppressed by the knockdown of human Myt1 in skin cancer cells. PMID: 19204086

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    MYT1 family
  • 组织特异性：
    Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.
  • 数据库链接：

    HGNC: 7622

    OMIM: 600379

    KEGG: hsa:4661

    STRING: 9606.ENSP00000327465

    UniGene: Hs.279562

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