MYOCD Antibody

1. Study shows that vascular endothelial growth factor A stimulates STAT3 activity via nitrosylation of myocardin to regulate the expression of vascular smooth muscle cell differentiation markers. PMID: 28572685
2. conditional knockout models have revealed a critical role for myocardin during cardiac chamber maturation, and a surprising function for myocardin in the regulation of cardiomyocyte proliferation, cell death, and possibly mitochondrial function. PMID: 28631251
3. YAP negatively regulates differentiation of Vascular smooth muscle cells (VSMCs) derived from cardiovascular progenitor cell (CVPC) by decreasing transcription of myocardin in a NKX2.5-dependent manner. PMID: 27571517
4. Myocardin inhibits estrogen receptor alpha-mediated proliferation of human breast cancer cells via regulating MicroRNA expression. PMID: 27156566
5. Key role for miR-214 in modulation of MEF2C-MYOCD-LMOD1 signaling. PMID: 27144530
6. Study demonstrates that myocardin indirectly down-regulates Cx43 through its repressive action on miR-206 to regulate vascular smooth muscle cell phenotypic switch. PMID: 28342807
7. These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity. PMID: 27403897
8. our study reveals that Ang II downregulates miR-145 to regulate Klf4 and myocardin expression in HCASMCs under high glucose conditions. Ang II plays a critical role in the regulation of miR-145 under hyperglycemic conditions PMID: 26181633
9. Human expression data disclosed correlations of MYOCD with CAV1 in a majority of human tissues and in the heart, correlation with MKL2 (MRTF-B) was observed. PMID: 26244347
10. inhibition of GSK-3beta reduces myocardin transcriptional activity, suggesting a role for GSK-3beta in myocardin transcriptional activity and smooth muscle differentiation PMID: 26129946
11. STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin and SRF. PMID: 26100622
12. TNFalpha differentially regulates myocardin expression and activity PMID: 25384061
13. Propose myocardin as a guardian of the contractile, noninflammatory VSMC phenotype, with loss of myocardin representing a critical permissive step in the process of phenotypic transition and inflammatory activation, at the onset of vascular disease. PMID: 25614278
14. it is probably that miR135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin PMID: 25190111
15. Early cardiac marker gene myocardin levels in peripheral blood mononuclear cells reflect severity in stable coronary artery disease. PMID: 24681789
16. Myocardin meditates apoptosis in breast cancer through affecting maspin re-expression and epigenetic modification. PMID: 24607789
17. the first evidence demonstrating that TEAD1 is a novel general repressor of smooth muscle-specific gene expression through interfering with myocardin binding to SRF. PMID: 24344135
18. ChIP analysis established that PDGF-BB-induced repression of Myocd gene expression is most likely regulated by enhanced binding of Klf4 and Klf5 to a lesser extent, to the PRR of PrmM PMID: 24060351
19. Myocardin increases the development and maturation of smooth muscle cell-like cells from human embryonic stem cells despite not activating the full repertoire of smooth muscle cell genes. PMID: 22937150
20. Hypertension negates the activity of myocardin in vascular smooth muscle cells. PMID: 22843699
21. Nuclear uPAR associates with myocardin, which is then recruited from the promoters of serum response factor target genes and undergoes proteasomal degradation. PMID: 22075245
22. Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. PMID: 21984848
23. Vascular smooth muscle proteasomal degradation of myocardin is required for its transcriptional activity. PMID: 21506120
24. Epigenetic inactivation of Myocardin is a frequent and tumor-specific event in nasopharyngeal carcinoma. PMID: 20848417
25. Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. PMID: 21051663
26. A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6. PMID: 20560679
27. These findings suggest a role of microRNA-1 in the negative feedback loop in the regulation of smooth muscle contractility induced by myocardin. PMID: 20458751
28. These results are the first to show relative expression and activities of the major myocardin isoforms across disparate spec PMID: 20385216
29. Results indicate that the downregulation of myocardin expression facilitates cell cycle progression via the reduction of p21 expression in human leimyosarcomas PMID: 20068148
30. the evaluation of myocardin expression is useful in distinguishing uterine smooth muscle tumors from endometrial stromal sarcomas PMID: 19952936
31. Myocardin was identified as a novel gene upregulated in human cervical ripening. PMID: 19883264
32. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype. PMID: 19801679
33. Myocardin is a critical serum response factor cofactor regulating smooth muscle cell differentiation; forced expression of myocardin activated expression of SM22 alpha, smooth muscle alpha-actin, and calponin-h1 genes in mouse ES cells PMID: 12640126
34. HERP1 and myocardin expression was localized to smooth muscle cells in the neointima in human coronary atherosclerotic lesions. PMID: 16151017
35. myocardin-MYOCD overexpression in small cerebral arteries appears to initiate independently of amyloid beta-peptide a pathogenic pathway mediating arterial hypercontractility PMID: 17215356
36. Myocardin is frequently repressed during malignant transformation, contributing to a differentiation defect PMID: 17292825
37. the SRC3-myocardin interaction is a site of convergence for nuclear hormone receptor-mediated and VSMC-specific gene regulation PMID: 17360478
38. Data show that fibroblasts from human postmyocardial infarction scars acquire properties of cardiomyocytes after transduction with a recombinant myocardin gene. PMID: 17579192
39. Forced expression of the myocardin (MyoC) gene in human ventricular scar fibroblasts leads to MyoC-dependent activation of genes that encode connexins, strongly enforcing intercellular electrical coupling. PMID: 17938287
40. data suggest that functional natural myocardin promoter variation might be a genetic factor contributing to inter-individual differences in the development of cardiac hypertrophy PMID: 18028454
41. Myocd is sufficient for the establishment of a SMC-like contractile phenotype. PMID: 18451334
42. Foxo3a could negatively regulate myocardin expression levels through up-regulating catalase and the consequent reduction of ROS levels PMID: 18772130
43. A rare human sequence variant reveals myocardin autoinhibition PMID: 18852265
44. We suggest that SRF and MYOCD function as a transcriptional switch, controlling Abeta cerebrovascular clearance and progression of AD. PMID: 19098903
45. Results show that human retroperitoneal LMS differentiation is dependent on MYOCD amplification/overexpression, suggesting that in these well-differentiated LMS, differentiation could be a consequence of an acquired genomic alteration. PMID: 19276386
46. analysis of a novel mode of modulation of SM gene transcription by ERK1/2 through a direct phosphorylation of myocardin PMID: 19776005
47. MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter PMID: 19797053

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HGNC: 16067

OMIM: 606127

KEGG: hsa:93649

STRING: 9606.ENSP00000401678

UniGene: Hs.462257