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  4. MIOX Antibody, HRP conjugated

MIOX Antibody, HRP conjugated

说明书
  • 中文名称：
    MIOX兔多克隆抗体, HRP偶联
  • 货号：
    CSB-PA866220LB01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MIOX Polyclonal antibody
  • Uniprot No.：
    Q9UGB7
  • 基因名：
    MIOX
  • 别名：
    0610009I10Rik antibody; AI314022 antibody; Aldehyde reductase-like 6 antibody; ALDRL6 antibody; C85427 antibody; Inositol oxygenase antibody; Kidney-specific protein 32 antibody; KSP32 antibody; MGC90217 antibody; MI oxygenase antibody; miox antibody; MIOX_HUMAN antibody; Myo-inositol oxygenase antibody; Renal-specific oxidoreductase antibody; RSOR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Inositol oxygenase protein (1-285AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    HRP
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶点详情

  • 基因功能参考文献：
    1. Our results suggest that serum MIOX levels do not change in polycystic ovary syndrome. It was, therefore, concluded that myoinositol deficiency observed in PCOS was not related to the level of MIOX enzyme which cleaves myoinositol. PMID: 29187000
    2. these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy. PMID: 28208054
    3. Data suggest that MIOX expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of MIOX activity is related to phosphorylation of serine/threonine residues. PMID: 26578517
    4. results demonstrated that the polymorphism (rs761745) in the promoter region of myo-inositol oxygenase(MIOX) gene may be associated with the development of type 1 diabetes mellitus in our studied population PMID: 19896870
    5. Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa protein. PMID: 15504367
    6. expression of MIOX is up-regulated by a positive feedback mechanism where xylitol, one of the products of MI catabolism via the glucuronate-xylulose pathway, induces an overexpression of MIOX PMID: 15778219
    7. myo-inositol oxygenase (MIOX) PMID: 11716759

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Myo-inositol oxygenase family
  • 组织特异性：
    Kidney specific.
  • 数据库链接：

    HGNC: 14522

    OMIM: 606774

    KEGG: hsa:55586

    STRING: 9606.ENSP00000216075

    UniGene: Hs.129227

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