MEAF6 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) MEAF6 Polyclonal antibody
Uniprot No.：

Q9HAF1
基因名：

MEAF6
别名：

MEAF6 antibody; C1orf149 antibody; CENP-28 antibody; EAF6Chromatin modification-related protein MEAF6 antibody; MYST/Esa1-associated factor 6 antibody; Esa1-associated factor 6 homolog antibody; Protein EAF6 homolog antibody; hEAF6 antibody; Sarcoma antigen NY-SAR-91 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Chromatin modification-related protein MEAF6 protein (113-174AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
基因功能参考文献：
1. These findings suggest that the MEAF6-1 variant does not induce neuroendocrine differentiation of prostate cancer cells, but rather facilitates t-NEPC progression by increasing the proliferation rate of cells that have acquired neuroendocrine phenotypes. PMID: 28427194
2. present two more ESS with MEAF6/PHF1 detected by transcriptome sequencing (case 1) and RT-PCR (case 2), proving that this fusion is recurrent in ESS PMID: 24530230
相关疾病：

A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1.
亚细胞定位：

Nucleus, nucleolus. Chromosome, centromere, kinetochore.
蛋白家族：

EAF6 family
数据库链接：

HGNC: 25674

OMIM: 611001

KEGG: hsa:64769

UniGene: Hs.17118