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  4. MCF2L Antibody

MCF2L Antibody

说明书
  • 中文名称：
    MCF2L兔多克隆抗体
  • 货号：
    CSB-PA521145ESR2HU
  • 规格：
    ￥440
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA521145ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA521145ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MCF2L Polyclonal antibody
  • Uniprot No.：
    O15068
  • 基因名：
    MCF2L
  • 别名：
    ARHGEF 14 antibody; DBL''s big sister antibody; DBS antibody; FLJ12122 antibody; Guanine nucleotide exchange factor DBS antibody; KIAA0362 antibody; MCF 2L antibody; MCF.2 cell line derived transforming sequence like antibody; MCF.2 transforming sequence-like antibody; MCF2 like protein antibody; MCF2 transforming sequence like protein antibody; MCF2-transforming sequence-like protein antibody; Mcf2l antibody; MCF2L_HUMAN antibody; OST antibody; OST oncogene antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Guanine nucleotide exchange factor DBS protein (850-980AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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MCF2L Proteins

靶点详情

  • 功能：
    Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42.; Does not catalyze guanine nucleotide exchange on CDC42.
  • 基因功能参考文献：
    1. When compared to the gemcitabine-sensitive cells, the gemcitabine-resistant cells had a higher level of MCF2L expression, suggesting that MCF2L plays an important role in gemcitabine resistance PMID: 29039610
    2. A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis. PMID: 25898923
    3. MCF2L is subject to a cis-acting eQTL in synovial membrane that correlates with the OA association signal. This signal contains several functional SNPs that could account for the susceptibility and which therefore merit further investigation PMID: 26584642
    4. A single nucleotide polymorphism in MCF2L is associated with osteoarthritis. PMID: 21871595
    5. Dbs is activated by Rac1 at the pleckstrin homology domain PMID: 14701795
    6. the guanine nucleotide exchange factor Ost has a role in negative regulation of receptor endocytosis by the small GTPase Rac1 PMID: 17562712

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  • 亚细胞定位：
    [Isoform 5]: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 3]: Cytoplasm. Endomembrane system.; Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    MCF2 family
  • 数据库链接：

    HGNC: 14576

    OMIM: 609499

    KEGG: hsa:23263

    STRING: 9606.ENSP00000440374

    UniGene: Hs.170422

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