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LRRFIP1 Antibody

说明书
  • 中文名称：
    LRRFIP1兔多克隆抗体
  • 货号：
    CSB-PA013175HA01HU
  • 规格：
    ￥440
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA013175HA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA013175HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA013175HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LRRFIP1 Polyclonal antibody
  • Uniprot No.：
    Q32MZ4
  • 基因名：
    LRRFIP1
  • 别名：
    FLAP 1 antibody; FLAP1 antibody; FLIIAP 1 antibody; FLIIAP1 antibody; GC binding factor 2 antibody; GC-binding factor 2 antibody; GCF 2 antibody; GCF2 antibody; HUFI 1 antibody; HUFI1 antibody; Leucine rich repeat (in FLII) interacting protein 1 antibody; Leucine rich repeat flightless interacting protein 1 antibody; Leucine-rich repeat flightless-interacting protein 1 antibody; LRR FLII interacting protein 1 antibody; LRR FLII-interacting protein 1 antibody; LRRF1_HUMAN antibody; LRRFIP 1 antibody; Lrrfip1 antibody; MGC10947 antibody; MGC119738 antibody; MGC119739 antibody; NEDD8 conjugating enzyme antibody; TAR RNA interacting protein antibody; TAR RNA-interacting protein antibody; Transcription factor 9 like antibody; TRIP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Leucine-rich repeat flightless-interacting protein 1 protein (1-315AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LRRFIP1 Antibody (CSB-PA013175HA01HU)，的标记方式是Non-conjugated。对于LRRFIP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013175HB01HU LRRFIP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA013175HC01HU LRRFIP1 Antibody, FITC conjugated
    Biotin CSB-PA013175HD01HU LRRFIP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
    Immunofluorescence (IF) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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LRRFIP1 Proteins

靶点详情

  • 功能：
    Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
  • 基因功能参考文献：
    1. Results show that LRRFIP-1 is mainly produced by keratinocytes in the unwounded skin but is upregulated in both keratinocytes and fibroblasts in response to wounding, suggesting a role in the wound repair process. PMID: 29996558
    2. Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/beta-catenin signaling pathway. PMID: 26047573
    3. High GCF2 expression is associated with hepatoma. PMID: 24761896
    4. Higher baseline LRRFIP1 expression in human glioblastoma multiforme tissue (n=60) is associated with better prognosis upon later treatment with teniposide. PMID: 24690174
    5. Data indicate that LRRFIP1 knockdown increased resting TNF mRNA level altered the ncRNA abundance at the LRRFIP1 binding region. PMID: 24567534
    6. Eight SNPs (rs7575941, rs3769053, rs11689421, rs3820808, rs11680012, rs3806505, rs6739130, and rs11686141) showed evidence of association with at least two adiposity phenotypes and plasma levels of one marker of inflammation. PMID: 23505185
    7. The FLI-interacting domain of LRRFIP1 forms a classic parallel, homodimeric coiled coil with 10 heptad repeats and 22 helical turns. PMID: 23099021
    8. GCF2/LRRFIP1 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion. PMID: 22750095
    9. LRRFIP1 is phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures. PMID: 21102652
    10. An association study of 6 of the 63 genes in 4235 cases and 6379 controls showed a putative association with myocardial infarction for COMMD7 (COMM domain-containing protein 7) and a major deviation from the null hypo thesis for LRRFIP1. PMID: 20833976
    11. GCF2/LRRFIP1 appears to act as a repressor and occupies the -308 site in cells that do not make TNF-alpha. PMID: 16199883
    12. Immediately following lipopolysaccharide stimulation, both LRRFIP2 and Flap-1/LRRFIP1 compete with Fliih for interacting with MyD88 to activate the signaling. PMID: 19265123

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    LRRFIP family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 6702

    OMIM: 603256

    KEGG: hsa:9208

    STRING: 9606.ENSP00000375857

    UniGene: Hs.471779

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