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LONP2 Antibody

  • 中文名称:
    LONP2兔多克隆抗体
  • 货号:
    CSB-PA060279
  • 规格:
    ¥1090
  • 其他:

产品详情

  • Uniprot No.:
  • 基因名:
    LONP2
  • 别名:
    Lon peptidase 2, peroxisomal antibody; Lon protease 2 antibody; Lon protease homolog 2 antibody; Lon protease homolog 2 peroxisomal antibody; Lon protease like protein 2 antibody; Lon protease-like protein 2 antibody; LONP antibody; lonp2 antibody; LONP2_HUMAN antibody; LONPL antibody; MGC4840 antibody; peroxisomal antibody; Peroxisomal Lon protease antibody; Peroxisomal Lon protease homolog 2 antibody; Peroxisomal LON protease like antibody
  • 宿主:
    Rabbit
  • 反应种属:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human LONP2.
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated
  • 抗体亚型:
    IgG
  • 纯化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式:
    Liquid
  • 应用范围:
    WB, IHC, ELISA
  • 推荐稀释比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

靶点详情

  • 功能:
    ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
  • 基因功能参考文献:
    1. Findings suggest that LONP2 promotes cervical tumorigenesis via oxidative stress. PMID: 29502128
    2. The proteolytic activity of oligomeric Tysnd1 is in turn controlled by self-cleavage of Tysnd1 and degradation of Tysnd1 cleavage products by PsLon. PMID: 22002062
    3. Lon recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites of MPPalpha and StAR, and generates unfolded polypeptides that are then processively degraded PMID: 15870080
  • 亚细胞定位:
    Peroxisome matrix.
  • 蛋白家族:
    Peptidase S16 family
  • 组织特异性:
    Widely expressed, with high levels in the liver, kidney and pancreas.
  • 数据库链接:

    HGNC: 20598

    OMIM: 617774

    KEGG: hsa:83752

    STRING: 9606.ENSP00000285737

    UniGene: Hs.295923