LGR6 Antibody

中文名称：

LGR6兔多克隆抗体
货号：

CSB-PA884515LA01HU
规格：

￥440
图片：
Western Blot
Positive WB detected in: U87 whole cell lysate
All lanes: LGR6 antibody at 2.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 105, 90, 100 kDa
Observed band size: 105 kDa

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA884515LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA884515LA01HU at dilution of 1:100
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产品名称：

Rabbit anti-Homo sapiens (Human) LGR6 Polyclonal antibody
Uniprot No.：

Q9HBX8
基因名：

LGR6
别名：

FLJ14471 antibody; Gonadotropin receptor antibody; GPCR antibody; Leucine rich repeat containing G protein coupled receptor 6 antibody; Leucine-rich repeat-containing G-protein coupled receptor 6 antibody; Lgr6 antibody; LGR6_HUMAN antibody; VTS20631 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 6 protein (839-962AA)
免疫原种属：

Homo sapiens (Human)

标记方式：

Non-conjugated

本页面中的产品，LGR6 Antibody (CSB-PA884515LA01HU)，的标记方式是Non-conjugated。对于LGR6 Antibody，我们还提供其他标记。见下表：

标记方式	货号	产品名称	应用
HRP	CSB-PA884515LB01HU	LGR6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA884515LC01HU	LGR6 Antibody, FITC conjugated
Biotin	CSB-PA884515LD01HU	LGR6 Antibody, Biotin conjugated	ELISA

克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, WB, IHC
推荐稀释比：

Application Recommended Dilution

WB 1:500-1:5000

IHC 1:20-1:200
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
基因功能参考文献：
1. Inhibition of LGR6 promoted the osteogenic differentiation of bone marrow stromal cells in vitro. PMID: 29625528
2. Lgr6 has a tumorpromoting role in the development of colorectal cancer. PMID: 29693156
3. Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance. PMID: 27798604
4. Two of the three monoclonal antibodies recognized the large N-terminal extracellular domain of leucine rich repeat containing G protein-coupled receptor 6 (LGR6), and competitively blocked the binding of R-spondin 1, which is known to be the ligand for LGR6. PMID: 28013222
5. LGR6 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
6. Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration. PMID: 22615920
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亚细胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
数据库链接：

HGNC: 19719

OMIM: 606653

KEGG: hsa:59352

STRING: 9606.ENSP00000356247

UniGene: Hs.497402

LGR6 Antibody

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Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200