LAX1 Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) LAX1 Polyclonal antibody
Uniprot No.：

Q8IWV1
基因名：

LAX1
别名：

LAX1 antibody; LAX antibody; Lymphocyte transmembrane adapter 1 antibody; Linker for activation of X cells antibody; Membrane-associated adapter protein LAX antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Lymphocyte transmembrane adapter 1 protein (107-298AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
基因功能参考文献：
1. TRIM required LAX for binding to Rab8 in a complex, a novel CTLA-4/TRIM/LAX/Rab8 effector complex in the transport of CTLA-4 to the surfaces of T cells PMID: 24515439
2. We identified the transmembrane domain of LAX as a first motif targeting transmembrane protein constructs to detergent-resistant heavy rafts, a novel type of membrane microdomains containing a number of physiologically important proteins. PMID: 22662118
3. functions to negatively regulate signaling in lymphocytes PMID: 12359715
4. inhibition of signaling events involved in T cell activation by LAX occurs through mechanisms both dependent on and independent of its tyrosine phosphorylation. PMID: 18981125
5. Overexpression of LAX in Jurkat cells specifically inhibits T cell receptor-mediated p38 MAPK activation and NFAT/AP-1 transcriptional activation. PMID: 12359715
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亚细胞定位：

Cell membrane; Single-pass type III membrane protein.
组织特异性：

Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.
数据库链接：

HGNC: 26005

KEGG: hsa:54900

STRING: 9606.ENSP00000406970

UniGene: Hs.272794