KCTD6 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) KCTD6 Polyclonal antibody
Uniprot No.：

Q8NC69
基因名：

KCTD6
别名：

BTB/POZ domain-containing protein KCTD6 antibody; KCASH3 antibody; kctd6 antibody; KCTD6_HUMAN antibody; MGC27385 antibody; potassium channel tetramerization domain containing 6 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
基因功能参考文献：
1. A biophysical characterization of the POZ/BTB of KCTD6, is reported. PMID: 24307990
2. Rescuing KCASHs expression reduces the Hedgehog-dependent medulloblastoma growth, suggesting that loss of members of this novel family of native HDAC inhibitors is crucial in sustaining Hh pathway-mediated tumorigenesis. PMID: 21472142
亚细胞定位：

Cytoplasm, myofibril, sarcomere, M line.
组织特异性：

Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.
数据库链接：

HGNC: 22235

KEGG: hsa:200845

STRING: 9606.ENSP00000347188

UniGene: Hs.13982