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  4. KCTD5 Antibody

KCTD5 Antibody

说明书
  • 中文名称：
    KCTD5兔多克隆抗体
  • 货号：
    CSB-PA012121GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NXV2
  • 基因名：
    KCTD5
  • 别名：
    BTB/POZ domain-containing protein KCTD5 antibody; FLJ20040 antibody; KCTD5 antibody; KCTD5_HUMAN antibody; Potassium channel tetramerisation domain containing 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KCTD5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
    Immunofluorescence (IF) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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KCTD5 Proteins

靶点详情

  • 功能：
    Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.
  • 基因功能参考文献：
    1. genetic modifier screen exposes suppressors of the KCTD5 phenotype and mechanistically demonstrates that KCTD5 acts as an off-switch for GPCR signalling by triggering proteolysis of Gbetagamma heterodimers dissociated from the Galpha subunit PMID: 28562590
    2. Identification of MCM7, ZNF711 and FAM193 as KCTD5 interaction partners.KCTD5 is not involved in polyubiquitylation of MCM7 replication factor.The KCTD5/cullin3 complex stabilizes ZNF711 transcription factor. PMID: 26188516
    3. we have identified a novel cellular AAV-2 Rep78/Rep68 interaction partner, KCTD5, located predominantly in the cytoplasm. PMID: 17239418
    4. Analysis of the interaction with cullin3 showed that, in addition to the BTB domain, some amino acids in the N-terminus of KCTD5 are required for binding to cullin3. Findings suggest that KCTD5 is a substrate-specific adaptor for cullin3-based E3 ligases PMID: 18573101
    5. structure reveals assemblies of five subunits while tetramers were anticipated; pentameric stoichiometry is observed also in solution by scanning transmission electron microscopy mass analysis and analytical ultracentrifugation PMID: 19361449

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasm. Nucleus.
  • 数据库链接：

    HGNC: 21423

    OMIM: 611285

    KEGG: hsa:54442

    STRING: 9606.ENSP00000301738

    UniGene: Hs.61960

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