KCNE3 Antibody, HRP conjugated

1. Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4 has been reported. PMID: 27922120
2. Structural, computational, biochemical, and electrophysiological studies lead to an atomically explicit integrative structural model of the KCNE3-KCNQ1 complex that explains how KCNE3 induces the constitutive activation of KCNQ1 channel activity, a crucial component in K(+) recycling. PMID: 27626070
3. Reported here are previously undiscovered protein-coding regions in exon 1 of hKCNE3 and hKCNE4 that extend their encoded extracellular domains by 44 and 51 residues, which yields full-length proteins of 147 and 221 residues, respectively. PMID: 27162025
4. Based on current evidence from published studies, neither of the two variants from KCNE was significantly associated with the risk of Meniere's disease--{REVIEW} PMID: 26890422
5. Data show that voltage-gated potassium channel KCNE3 directly affects the S4 movement in potassium channel KCNQ1. PMID: 26668384
6. KCNQ1/KCNE3 channels make only a small contribution to basolateral conductance in normal colonic crypts, with increased channel activity in UC appearing insufficient to prevent colonic cell depolarization in this disease. PMID: 26718405
7. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation PMID: 26410412
8. A KCNE3 T4A mutation was identified in a Japanese patient presenting Brugada-pattern ECG and neurally mediated syncope. PMID: 22987075
9. Allele frequencies are studied for 11 known variants of KCNE3 gene, of which two (F66F and R83H) are polymorphic but are not associated with chronic tinnitus. PMID: 21899751
10. The results of this study indicated that Kv7.5 contributes to the spatial regulation. PMID: 22190306
11. 2 of the 8 MiRP2 extracellular domain acidic residues (D54 and D55) are important for KCNQ1-MiRP2 constitutive activation. PMID: 20040519
12. data show that SNPs in KCNE1 and KCNE3 are not associated with Meniere disease in Caucasians PMID: 20034061
13. The KCNE3 protein within the micellesis in monomeric form and acquires mainly alpha-helical conformation. PMID: 19961415
14. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. PMID: 11956246
15. The authors found MiRP2-R83H in 3 of 321 control subjects and in 5 unaffected related individuals. Provocation of an unaffected carrier with glucose or KCl did not induce weakness. PMID: 15037716
16. interaction of MiRP2-72 with KCNQ1-338; and MinK-59,58 with KCNQ1-339, 340 PMID: 16308347
17. The result indicates that 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene could determine an increased susceptibility to develop MD. PMID: 16374062
18. The characterization of a missense mutation in MiRP2 that affects its phosphorylation and consequent interactions with Kv3.4 is reported. PMID: 16449802
19. KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2 PMID: 16782062
20. Up-regulation and incrased activity of KV3.4 channels and their accessory subunit Mirp2 induced by amyloid peptide are involved in apoptotic neuronal death. PMID: 17495071
21. Abnormalities in the KCNE3 gene is a potential genetic risk factor for initiation and/or maintenance of atrial fibrillation. PMID: 18209471
22. KCNE3 plays a functional role in the modulation of I(to) in the human heart and suggest that mutations in KCNE3 can underlie the development of BrS. PMID: 19122847

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HGNC: 6243

OMIM: 604433

KEGG: hsa:10008

STRING: 9606.ENSP00000310557

UniGene: Hs.523899