KCMF1 Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) KCMF1 Polyclonal antibody
Uniprot No.：

Q9P0J7
基因名：

KCMF1
别名：

KCMF1 antibody; FIGC antibody; ZZZ1 antibody; E3 ubiquitin-protein ligase KCMF1 antibody; EC 2.3.2.27 antibody; FGF-induced in gastric cancer antibody; Potassium channel modulatory factor antibody; PCMF antibody; RING-type E3 ubiquitin transferase KCMF1 antibody; ZZ-type zinc finger-containing protein 1 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase KCMF1 protein (98-226AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
基因功能参考文献：
1. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4. PMID: 25582440
2. Data indicate that expressions of miR-210 and potassium channel modulatory factor 1 (KCMF1) exhibited an inverse correlation in placentas from patients with severe preeclampsia. PMID: 24980667
3. Data indicate that FIGC upregulation in response to basic fibroblast growth factor in gastric cancer might be implicated in carcinogenesis through dysregulation of growth modulator. PMID: 15581609
4. Suppression of KCMF1 by constitutive high CD99 expression levels contribute to the malignant properties of Ewing's sarcoma by promoting growth and migration of tumor cells PMID: 16314831
蛋白家族：

KCMF1 family
组织特异性：

Spleen, small intestine, ovary, peripheral blood, lung, kidney and pancreas. Expressed at low levels in the thymus, prostate, testis, colon, heart, brain, placenta and liver.
数据库链接：

HGNC: 20589

OMIM: 614719

KEGG: hsa:56888

STRING: 9606.ENSP00000386738

UniGene: Hs.654968