KBTBD7 Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) KBTBD7 Polyclonal antibody
Uniprot No.：

Q8WVZ9
基因名：

KBTBD7
别名：

Kelch repeat and BTB domain-containing protein 7, KBTBD7
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Kelch repeat and BTB domain-containing protein 7 protein (475-684aa)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex.
基因功能参考文献：
1. KBTBD6 and KBTBD7 specifically bind to GABARAP proteins.KBTBD6 and KBTBD7 form a heterodimeric CRL3 complex. PMID: 25684205
2. KBTBD7 proteins may act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. PMID: 20132730
亚细胞定位：

Cytoplasm. Nucleus.
数据库链接：

HGNC: 25266

OMIM: 617739

KEGG: hsa:84078

STRING: 9606.ENSP00000368797

UniGene: Hs.594902